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Permanent link (DOI): https://doi.org/10.7939/R3TM7284H

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Corticospinal Tract Integrity in Acute Intracerebral Hemorrhage Open Access

Descriptions

Other title
Subject/Keyword
Stroke
Intracerebral Hemorrhage
Magnetic Resonance Imaging
Diffusion Tensor Imaging
Corticospinal Tract
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
McCourt, Rebecca C
Supervisor and department
Butcher, Ken (Faculty of Medicine and Dentistry)
Examining committee member and department
Camicioli, Richard (Faculty of Medicine and Dentistry)
Beaulieu, Christian (Biomedical Engineering)
Department
Centre for Neuroscience
Specialization

Date accepted
2016-09-28T10:51:47Z
Graduation date
2016-06:Fall 2016
Degree
Master of Science
Degree level
Master's
Abstract
Background: Intracerebral Hemorrhage (ICH) is associated with high morbidity and patients commonly suffer motor dysfunction. ICH volume is a significant predictor of outcome, and perihematoma edema may also represent tissue injury. Diffusion Tensor Imaging (DTI) can be used to assess in-vivo changes in tissue microstructure in white matter tracts, such as the Corticospinal Tract (CST). Using DTI, the deleterious effects of the hematoma and perihematoma edema on CST integrity and motor outcome may be assessed. Methods: Patients with primary ICH underwent DTI at 72h, and days 7 and 30 after symptom onset. Diffusion metrics including Fractional Anisotropy (FA), a diffusion-based correlate for white matter integrity, were measured through the entire CST. Diffusion was also measured in the region of the ipsilateral CST that passed through the edema. Results: DTI demonstrates evidence of impairment in the CST after ICH. Larger hematoma volumes were associated with lower FA values at day 30 (β= -0.77; p=0.003). FA was decreased in the CST where it passes through the edema, but was not related to motor outcome. Conclusions: This study provides insight into the mechanisms of functional disability following hemorrhagic stroke. Hematoma volume is a mediating factor in white matter change after ICH, but diffusion changes in the perihematoma edema do not appear to be related to tract impairment.
Language
English
DOI
doi:10.7939/R3TM7284H
Rights
This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for the purpose of private, scholarly or scientific research. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
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