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Permanent link (DOI): https://doi.org/10.7939/R3SN01J04

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Comparative genomics of Lactobacillus reuteri from sourdough reveals adaptation of an intestinal symbiont to food fermentations Open Access

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Author or creator
Zheng, Jinshui
Zhao, Xin
Lin, Xiaoxi B.
Gänzle, Michael G.
Additional contributors
Subject/Keyword
Recombination
Biodiversity
Positive Selection
Carbohydrate
Protein-Sequence Alignments
Lactic-Acid Bacteria
Sanfranciscensis
Phylogenetic Analysis
Evolution
Metabolism
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Lactobacillus reuteri is a dominant member of intestinal microbiota of vertebrates, and occurs in food fermentations. The stable presence of L. reuteri in sourdough provides the opportunity to study the adaptation of vertebrate symbionts to an extra-intestinal habitat. This study evaluated this adaptation by comparative genomics of 16 strains of L. reuteri. A core genome phylogenetic tree grouped L. reuteri into 5 clusters corresponding to the host-adapted lineages. The topology of a gene content tree, which includes accessory genes, differed from the core genome phylogenetic tree, suggesting that the differentiation of L. reuteri is shaped by gene loss or acquisition. About 10% of the core genome (124 core genes) were under positive selection. In lineage III sourdough isolates, 177 genes were under positive selection, mainly related to energy conversion and carbohydrate metabolism. The analysis of the competitiveness of L. reuteri in sourdough revealed that the competitivess of sourdough isolates was equal or higher when compared to rodent isolates. This study provides new insights into the adaptation of L. reuteri to food and intestinal habitats, suggesting that these two habitats exert different selective pressure related to growth rate and energy (carbohydrate) metabolism.
Date created
2015
DOI
doi:10.7939/R3SN01J04
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Attribution 4.0 International
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Zheng, Jinshui, Zhao, Xin, Lin, Xiaoxi B., & Gänzle, Michael G. (2015). Comparative genomics of Lactobacillus reuteri from sourdough reveals adaptation of an intestinal symbiont to food fermentations. Scientific Reports, 5, [11].  http://dx.doi.org/10.1038/srep18234

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File format: pdf (Portable Document Format)
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Copyright note: © 2015 Nature Publishing Group
File title: Comparative genomics Lactobacillus reuteri from sourdough reveals adaptation of an intestinal symbiont to food fermentations
File author: Jinshui Zheng
Page count: 11
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