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Permanent link (DOI): https://doi.org/10.7939/R3R20S46K

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Modeling brain lentiviral infections during antiretroviral therapy in AIDS Open Access

Descriptions

Other title
Subject/Keyword
mathematical model
brain macrophage
human immunodeficiency virus-1
HIV-1
simian immunodeficiency virus
SIV
combination antiretroviral therapy
cART
brain
reservoir
lentiviral
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Roda, Weston C
Supervisor and department
Li, Michael (Department of Mathematical and Statistical Sciences)
Power, Christopher (Division of Neurology, Department of Medicine)
Examining committee member and department
Yi, Yingfei (Department of Mathematical and Statistical Sciences)
Li, Michael (Department of Mathematical and Statistical Sciences)
Power, Christopher (Division of Neurology, Department of Medicine)
Wang, Hao (Department of Mathematical and Statistical Sciences)
Department
Department of Mathematical and Statistical Sciences
Specialization
Applied Mathematics
Date accepted
2016-09-16T10:46:17Z
Graduation date
2016-06:Fall 2016
Degree
Master of Science
Degree level
Master's
Abstract
Understanding human immunodeficiency-1 (HIV-1) replication and latency in different reservoirs is an ongoing challenge in the care of patients with HIV/AIDS. A mathematical model was created that predicted HIV-1 and simian immunodeficiency virus (SIV) infection dynamics within the brain during effective combination antiretroviral therapy (cART). By developing a two compartment mathematical approach, a predictive model was generated from existing empiric data. Based on previous reports quantifying total viral DNA levels in brain from HIV-1 and SIV infections, estimates of proviral DNA burden were made, which were fit to a mathematical model predicting viral accrual in brain macrophages from primary infection. To our knowledge this is the first mathematical modeling study to quantify HIV-1 and SIV infection dynamics in the brain. Our modeling study indicates that HIV-1 and SIV provirus burdens in brain increase slowly over time. Assuming antiretroviral therapy suppresses HIV-1 infection outside the brain, an effective antiretroviral therapy could eradicate HIV-1 infection in the brain, albeit over a decade for patients without neurological complications and over two decades for those with HAND.
Language
English
DOI
doi:10.7939/R3R20S46K
Rights
This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for the purpose of private, scholarly or scientific research. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
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