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Permanent link (DOI): https://doi.org/10.7939/R3XG9FQ7N

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Transcriptional regulation of lipid metabolism: A key determinant of pancreatic ß-cell function Open Access

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Author or creator
Fatehi-Hassanabad, Zahra
Chan, Catherine B.
Additional contributors
Subject/Keyword
Pancreatic Beta Cells
Diabetes -- Research
Lipid Metabolism
Fatty Acids In Human Nutrition
Homeostasis
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Background Optimal pancreatic β-cell function is essential for the regulation of glucose homeostasis in both humans and animals and its impairment leads to the development of diabetes. Type 2 diabetes is a polygenic disease aggravated by environmental factors such as low physical activity or a hypercaloric high-fat diet. Results Free fatty acids represent an important factor linking excess fat mass to type 2 diabetes. Several studies have shown that chronically elevated free fatty acids have a negative effect on β-cell function leading to elevated insulin secretion basally but with an impaired response to glucose. The transcription factors PPARα, PPARγ and SREBP-1c respond to changing fat concentrations in tissues, thereby coordinating the genomic response to altered metabolic conditions to promote either fat storage or catabolism. These transcription factors have been identified in β-cells and it appears that each may exert influence on β-cell function in health and disease. Conclusion The role of the PPARs and SREBP-1c as potential mediators of lipotoxicity is an emerging area of interest.
Date created
2005
DOI
doi:10.7939/R3XG9FQ7N
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Attribution 4.0 International
Citation for previous publication
Fatehi-Hassanabad, Z., & Chan, C. B. (2005). Transcriptional regulation of lipid metabolism: A key determinant of pancreatic ß-cell function. Nutrition & Metabolism, 2(1), [12 pages].  http://dx.doi.org/10.1186/1743-7075-2-1

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