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Permanent link (DOI): https://doi.org/10.7939/R3ZP3WD4N

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Vaccenic and elaidic acid modify plasma and splenocyte membrane phospholipids and mitogen-stimulated cytokine production in obese insulin resistant JCR:LA-cp rats Open Access

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Author or creator
Ruth, Megan R.
Wang, Ye
Yu, Howe-Ming
Goruk, Susan
Reaney, Martin J.
Proctor, Spencer D.
Vine, Donna F.
Field, Catherine J.
Additional contributors
Subject/Keyword
Vaccenic Acid
Inflammation
Cytokines
Immune
Obese
Phospholipid
Elaidic Acid
Trans Fat
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
This study assessed the long-term effects of dietary vaccenic acid (VA) and elaidic acid (EA) on plasma and splenocyte phospholipid (PL) composition and related changes in inflammation and splenocyte phenotypes and cytokine responses in obese/insulin resistant JCR:LA-cp rats. Relative to lean control (Ctl), obese Ctl rats had higher serum haptoglobin and impaired T-cell-stimulated cytokine responses. VA and EA diets improved T-cell-stimulated cytokine production; but, only VA normalized serum haptoglobin. However, EA- and VA-fed rats had enhanced LPS-stimulated cytokine responses. The changes elicited by VA were likely due changes in essential fatty acid composition in PL; whereas EA-induced changes may due to direct incorporation into membrane PL.
Date created
2010
DOI
doi:10.7939/R3ZP3WD4N
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Attribution 4.0 International
Citation for previous publication
Ruth, M. R., Wang, Y., Yu, H. -M., Goruk, S., Reaney, M. J., Proctor, S., Vine, D. F., & Field, C. J. (2010). Vaccenic and elaidic acid modify plasma and splenocyte membrane phospholipids and mitogen-stimulated cytokine production in obese insulin resistant JCR:LA-cp rats. Nutrients, 2(2), 181-197.  http://dx.doi.org/10.3390/nu2020181

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