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Permanent link (DOI): https://doi.org/10.7939/R3N58CX05

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Evidence for the functional and structural differentiation of the inferior fronto-occipital fasciculus using DTI tractography Open Access

Descriptions

Other title
Subject/Keyword
DTI
Inferior fronto-occipital fasciculus
Tractography
Naming
Go/no-go
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Rollans, Claire
Supervisor and department
Cummine, Jacqueline (Communication Sciences and Disorders)
Examining committee member and department
Boliek, Carol (Communication Sciences and Disorders)
Charest, Monique (Communication Sciences and Disorders)
Department
Faculty of Rehabilitation Medicine
Specialization

Date accepted
2016-05-31T11:23:32Z
Graduation date
2016-06
Degree
Master of Science
Degree level
Master's
Abstract
The inferior fronto-occipital fasciculus (IFOF), a major ventral white matter pathway, has been shown to be a crucial component of semantic (Moritz-Gasser, Herbet & Duffau, 2013) and lexical/orthographic (Vandermosten, Boets, Polemans, Sunaert, Wouters & Ghesquière, 2012) processing. However, recent anatomical studies of the brain have revealed at least two differentiable components of the IFOF: a dorsal component projecting from the frontal lobe to the superior parietal lobule, and a ventral component connecting the frontal lobe with the inferior occipital gyrus and posterior temporal lobe (Martino, Brogna, Robles, Vergani & Duffau, 2010). We have replicated this anatomical division using a new deterministic tractography protocol in DTI Studio, and found this protocol to have high inter-rater reliability (ICC > 0.9). Furthermore, we provided the first evidence of a functional distinction between these two components. We compared diffusion measures (e.g., fractional anisotropy [FA], an indirect measure of white matter microstructural integrity) with reaction times on five different reading tasks: basic naming of pure exception words, regular words, and mixed exception/regular words, and go/no-go tasks involving either pseudohomophone or nonword foils. We found a clear functional divide in the left IFOF, whereby dorsal FA was specifically correlated with performance on tasks that required higher levels of visual attention and response selection (go/no-go and mixed naming tasks), while ventral FA was more broadly correlated with naming performance. This demonstrates that the anatomical distinction described by Martino et al. (2010) is indeed mirrored by a functional distinction, and suggests that future investigations of neuroanatomical models of reading and speech production should consider the dorsal and ventral IFOF as separate entities.
Language
English
DOI
doi:10.7939/R3N58CX05
Rights
This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for the purpose of private, scholarly or scientific research. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
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