ERA

Download the full-sized PDF of High-fructose feeding of streptozotocin-diabetic rats is associated with increased cataract formation and increased oxidative stress in the kidneyDownload the full-sized PDF

Analytics

Share

Permanent link (DOI): https://doi.org/10.7939/R3VT1H357

Download

Export to: EndNote  |  Zotero  |  Mendeley

Communities

This file is in the following communities:

Agricultural, Food and Nutritional Science, Department of

Collections

This file is in the following collections:

Journal Articles (Agricultural, Food and Nutritional Science)

High-fructose feeding of streptozotocin-diabetic rats is associated with increased cataract formation and increased oxidative stress in the kidney Open Access

Descriptions

Author or creator
Bell, R. C.
​Carlson, J. C.
Storr, K. C.
Herbert, K.
Sivak, J.
Additional contributors
Subject/Keyword
Cataracts
Diabetes
Oxidative Damage
Fructose
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
We examined the effects of high-fructose (FR) feeding on the development of diabetic complications in the lens and the kidney of streptozotocin (STZ)-diabetic rats. Male Wistar Furth rats were treated with one of two doses of STZ (HIGH STZ, 55 mg/kg body weight; MOD STZ, 35 mg/kg body weight) or vehicle alone (SHAM) and were then assigned to a control (CNTL) or 400 g FR/kg diet for 12 weeks. At the end of the study, body weight, plasma glucose and insulin concentrations differed among STZ groups (HIGH v. MOD v. SHAM, P<0·001) but did not differ due to diet. Plasma FR concentrations were significantly higher in FR-fed v. CNTL-fed groups (P<0·0001) and in HIGH-STZ groups v. MOD-STZ and SHAM groups (P<0·0004 and P<0·0001 respectively). Focal length variability of the lens, a quantitative measure of cataract formation, was increased in the HIGH STZ, FR group compared with the HIGH STZ, CNTL group (P<0·01). The concentration of H2O2 in kidney microsomes was significantly higher in HIGH STZ, FR rats v. HIGH STZ, CNTL rats (P<0·01). Microalbuminuria was not observed in any of the groups examined, and there was no evidence of extensive histological damage in the kidney from any rats. Under conditions of severe hyperglycaemia, high FR intake promotes the development of cataracts in the lens of the eye, and results in increased concentrations of substances indicative of oxidative stress in the kidney. Although FR has been suggested as a carbohydrate source for diabetics, a high FR diet coupled with hyperglycaemia produces effects that may promote some of the complications associated with diabetes.
Date created
2000
DOI
doi:10.7939/R3VT1H357
License information
© The Nutrition Society 2000
Rights

Citation for previous publication
Bell, R. C., ​Carlson, J. C., Storr, K. C., Herbert, K., & Sivak, J. (2000). High-fructose feeding of streptozotocin-diabetic rats is associated with increased cataract formation and increased oxidative stress in the kidney. British Journal of Nutrition, 84(4), 575-­582.  http://dx.doi.org/10.1017/S0007114500001896

Source

Link to related item

File Details

Date Uploaded
Date Modified
Audit Status
Audits have not yet been run on this file.
Characterization
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 175785
Last modified: 2017:09:06 16:05:52-06:00
Filename: BJN_84_4_575.pdf
Original checksum: 8e3654319e7542ca287f86c59fad1469
Well formed: true
Valid: true
File title: High-fructose feeding of streptozotocin-diabetic rats is associated with increased cataract formation and increased oxidative stress in the kidney
File author: Rhonda C. Bell, John C. Carlson, Katrina C. Storr, Kelley Herbert and Jacob Sivak
Page count: 8
Activity of users you follow
User Activity Date