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Permanent link (DOI): https://doi.org/10.7939/R3R20S96T

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The Functional Role of Hippocampal Subregions and Subfields: A High-Resolution fMRI Study of Memory Open Access

Descriptions

Other title
Subject/Keyword
Hippocampus
Memory
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
MacGillivray, Melanie, C
Supervisor and department
Malykhin, Nikolai (Biomedical Engineering)
Examining committee member and department
Caplan, Jeremy (Psychology)
Dickson, Clayton (Psychology)
Smith, Peter (Pharmacology)
Cummine, Jacqueline (Communication Sciences and Disorders)
Department
Neuroscience
Specialization

Date accepted
2017-07-28T11:09:50Z
Graduation date
2017-11:Fall 2017
Degree
Master of Science
Degree level
Master's
Abstract
The involvement of the hippocampus in episodic memory is well accepted. What is often overlooked is the involvement of hippocampal subfields and subregions. The hippocampal subfields Cornu Ammonis (CA), Dentate Gyrus (DG) and Subiculum (Sub) are cellularly distinct areas that communicate transversely across the hippocampus, while hippocampal subregions (Head, Body & Tail) are delineated from anterior to posterior along the length of the hippocampus and have different cortical connectivity. The current study addressed the question of how hippocampal subfields and subregions are involved in the encoding of episodic memory using high-resolution fMRI and an adaptation of the Wechsler Memory Scale Designs Subtest (2009). Our memory tasks consisted of 3 conditions: Symbol (content memory), Location (spatial memory) and Both (associative memory). We found that the total hippocampus was active for the Symbol, Location and Both conditions. All subfields and subregions were active across all conditions of the task relative to baseline. DG activity was significantly larger than CA activity when averaged across conditions. For the Location condition the hippocampal tail was more active than the hippocampal body, suggesting it may play a more dominant role in spatial memory. In addition hemisphere by subfield and subfield by condition interactions were observed. Our results provide support for the theory of posterior hippocampal involvement in spatial memory, and suggest the human hippocampus works in discrete but connected subsections to encode episodic memory.
Language
English
DOI
doi:10.7939/R3R20S96T
Rights
This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for the purpose of private, scholarly or scientific research. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
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Last modified: 2017:11:08 17:48:08-07:00
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