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Emerging pathways in the regulation of whole body cholesterol flux: Therapeutic opportunities to target atherosclerosis? Open Access

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Author or creator
Mangat, Rabban
Proctor, Spencer D.
Additional contributors
Subject/Keyword
Animals
Liver/Metabolism
Carrier Proteins/Metabolism
Carrier Proteins/Antagonists & Inhibitors
Cholesterol/Metabolism
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
INTRODUCTION: CVD remains one of the most frequent causes of morbidity and mortality globally. Increased awareness of lifestyle factors (nutrition/exercise), as well as the refinement of lipid-lowering therapies, has availed some progress in reducing the incidence of CVD. Historically, the hepatic regulation of lipid and cholesterol homeostasis and its contribution to CVD has been the primary focus of research to target lipid-lowering therapy. However, breakthroughs in the understanding of how the intestine complements the liver in whole-body cholesterol homeostasis have provided new advances in our approach to anti-atherosclerotic targets.
Date created
2014
DOI
doi:10.7939/R3XW4891J
License information
© 2014 by the American Society for Biochemistry and Molecular Biology, Inc.
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Citation for previous publication
Mangat, R., & Proctor, S. D. (2014). Emerging pathways in the regulation of whole body cholesterol flux: Therapeutic opportunities to target atherosclerosis? Journal of Lipid Research, 55(5), 796-797.  http://dx.doi.org/10.1194%2Fjlr.E049502

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