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Initial differences in lipid processing leading to pig- and beef-derived mature adipocyte dedifferentiation Open Access
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Fernyhough, Melinda E.
Hausman, Gary J.
Dodson, Michael V.
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Clonal cultures of pig-derived mature adipocytes are capable of dedifferentiating and forming proliferative-competent progeny cells in vitro. Initial lipid processing, is different to that observed in cultures of beef-derived adipocytes. Mature pig adipocytes extrude lipid before proliferation, whereas beef-derived adipocytes symmetrically, or asymmetrically, divide without expelling lipid. These observations suggest that dedifferentiation of mature adipocytes relies on species-specific mechanisms, or that different culture conditions are required for pigderived adipocytes to dedifferentiate in a manner similar to beef adipocytes. This in vitro system will aid in our understanding of lipid metabolism, regulation of single cells, processes involved in dedifferentiation of cells, and/or characteristics of putative stem cells residing in adipose tissue.
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Chen, J., Guridi, M., Fernyhough, M. E., Jiang, Z., Guan, L. L., Hausman, G. J., & Dodson, M. V. (2009). Initial differences in lipid processing leading to pig- and beef-derived mature adipocyte dedifferentiation. Basic and Applied Myology, 19(5-6), 243-246. Retrieved from: http://www.bio.unipd.it/bam/bam19-5&6.html
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