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Permanent link (DOI): https://doi.org/10.7939/R3HM52Z6W

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Dietary fish oil reduces glomerular injury and improves elevated renal hydroxyeicosatetraenoic acid levels in the JCR:LA-cp rat, a model of the metabolic syndrome Open Access

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Author or creator
Aukema, Harold
Lu, Jing
Borthwick, Faye
Proctor, Spencer D.
Additional contributors
Subject/Keyword
Fish Oil (n-3 PUFA)
Metabolic Syndrome
Renal Disease
Eicosanoids
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
We have previously shown nutritional intervention with fish oil (n-3 PUFA) to reduce numerous complications associated with the metabolic syndrome (MetS) in the JCR:LA-corpulent (cp) rat. In the present study, we sought to explore the potential role of fish oil to prevent glomerulosclerosis in JCR:LA-cp rats via renal eicosanoid metabolism and lipidomic analysis. Male lean and MetS JCR:LA-cp rats were fed a lipid-balanced diet supplemented with fish oil (5 or 10 % of total fat). After 16 weeks of feeding, albuminuria was significantly reduced in MetS rats supplemented with 5 or 10 % fish oil ( − 53 and − 70 %, respectively, compared with the untreated MetS rats). The 5 % fish oil diet resulted in markedly lower glomerulosclerosis ( − 43 %) in MetS rats and to a lesser extent in those supplemented with 10 % fish oil. Interestingly, untreated MetS rats had higher levels of 11- and 12-hydroxyeicosatetraenoic acids (HETE) v. lean rats. Dietary fish oil reduced these levels, as well as other (5-, 9- and 15-) HETE. Whilst genotype did not alter prostanoid levels, fish oil reduced endogenous renal levels of 6-keto PGF1α (PGI2 metabolite), thromboxane B2 (TxB2), PGF2α and PGD2 by approximately 60 % in rats fed 10 % fish oil, and TxB2 ( − 50 %) and PGF2α ( − 41 %) in rats fed 5 % fish oil. In conclusion, dietary fish oil prevented glomerular damage in MetS rats and mitigated the elevation in renal HETE levels. These results suggest a potential role for dietary fish oil to improve dysfunctional renal eicosanoid metabolism associated with kidney damage during conditions of the MetS.
Date created
2012
DOI
doi:10.7939/R3HM52Z6W
License information
© The Authors 2012
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Citation for previous publication
Aukema, H., Lu, J., Borthwick, F., & Proctor, S. D. (2012). Dietary fish oil reduces glomerular injury and improves elevated renal hydroxyeicosatetraenoic acid levels in the JCR:LA-cp rat, a model of the metabolic syndrome. British Journal of Nutrition, 110(1), 11-19.  http://dx.doi.org/10.1017/S0007114512004606

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