ERA

Download the full-sized PDF of Genome-wide association studies (GWAS) identify a QTL close to PRKAG3 affecting meat pH and colour in crossbred commercial pigsDownload the full-sized PDF

Analytics

Share

Permanent link (DOI): https://doi.org/10.7939/R3SJ19V57

Download

Export to: EndNote  |  Zotero  |  Mendeley

Communities

This file is in the following communities:

Roy Berg Kinsella Research Ranch

Collections

This file is in the following collections:

Journal Articles (Kinsella Ranch)

Genome-wide association studies (GWAS) identify a QTL close to PRKAG3 affecting meat pH and colour in crossbred commercial pigs Open Access

Descriptions

Author or creator
Zhang, Z.
Wang, Z.
Bruce, H.
Kemp, R. A.
Charagu, P.
Miar, Y.
Yang, T.
Plastow, G. S.
Additional contributors
Subject/Keyword
snp
genome-wide association studies
meat ph and colour
pig
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Background Improving meat quality is a high priority for the pork industry to satisfy consumers’ preferences. GWAS have become a state-of-the-art approach to genetically improve economically important traits. However, GWAS focused on pork quality are still relatively rare. Results Six genomic regions were shown to affect loin pH and Minolta colour a* and b* on both loin and ham through GWAS in 1943 crossbred commercial pigs. Five of them, located on Sus scrofa chromosome (SSC) 1, SSC5, SSC9, SSC16 and SSCX, were associated with meat colour. However, the most promising region was detected on SSC15 spanning 133–134 Mb which explained 3.51% - 17.06% of genetic variance for five measurements of pH and colour. Three SNPs (ASGA0070625, MARC0083357 and MARC0039273) in very strong LD were considered most likely to account for the effects in this region. ASGA0070625 is located in intron 2 of ZNF142, and the other two markers are close to PRKAG3, STK36, TTLL7 and CDK5R2. After fitting MARC0083357 (the closest SNP to PRKAG3) as a fixed factor, six SNPs still remained significant for at least one trait. Four of them are intragenic with ARPC2, TMBIM1, NRAMP1 and VIL1, while the remaining two are close to RUFY4 and CDK5R2. The gene network constructed demonstrated strong connections of these genes with two major hubs of PRKAG3 and UBC in the super-pathways of cell-to-cell signaling and interaction, cellular function and maintenance. All these pathways play important roles in maintaining the integral architecture and functionality of muscle cells facing the dramatic changes that occur after exsanguination, which is in agreement with the GWAS results found in this study. Conclusions There may be other markers and/or genes in this region besides PRKAG3 that have an important effect on pH and colour. The potential markers and their interactions with PRKAG3 require further investigation
Date created
2015
DOI
doi:10.7939/R3SJ19V57
License information
Attribution 4.0 International
Rights

Citation for previous publication
Zhang, Z., Wang, Z., Bruce, H., Kemp, R.A., Charagu, P., Miar, Y., Yang, T., Plastow, G.S. (2015). Genome-wide association studies (GWAS) identify a QTL close to PRKAG3 affecting meat pH and colour in crossbred commercial pigs, BMC Genetics, 16(33)
Source
Link to related item

File Details

Date Uploaded
Date Modified
Audit Status
Audits have not yet been run on this file.
Characterization
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 3131517
Last modified: 2016:06:24 17:30:44-06:00
Filename: BMC_GEN_16_33_2015
Original checksum: c98ba20abe0dd428d99e374ef10f8ebd
Copyright note: ??? 2015 Zhang et al.; licensee BioMed Central.
Well formed: true
Valid: false
Status message: Invalid destination object offset=2838562
Status message: Invalid destination object offset=2838562
Status message: Invalid destination object offset=2838562
Status message: Invalid destination object offset=2838562
Status message: Invalid destination object offset=2838562
File title: Abstract
File title: Genome-wide association studies (GWAS) identify a QTL close to PRKAG3 affecting meat pH and colour in crossbred commercial pigs
File author: Chunyan Zhang
Page count: 12
Activity of users you follow
User Activity Date