Download the full-sized PDF
Permanent link (DOI): https://doi.org/10.7939/R3S46HK7V
This file is in the following communities:
|Agricultural, Food and Nutritional Science, Department of|
This file is in the following collections:
|Journal Articles (Agricultural, Food and Nutritional Science)|
Role of mitochondria in toxic oxidative stress Open Access
- Author or creator
Fariss, M. W.
Chan, C. B.
van Houten, B.
- Additional contributors
Diabetes Mellitus, Type 2/Metabolism
Reactive Oxygen Species
Dose-Response Relationship, Drug
- Type of item
- Journal Article (Published)
Oxidative stress and mitochondrial oxidative damage have been implicated in the etiology of numerous common diseases. The critical mitochondrial events responsible for oxidative stress–mediated cell death (toxic oxidative stress), however, have yet to be defined. Several oxidative events implicated in toxic oxidative stress include alterations in mitochondrial lipids (e.g., cardiolipin), mitochondrial DNA, and mitochondrial proteins (eg. aconitase and uncoupling protein 2). Furthermore, recent findings indicate the enrichment of mitochondrial membranes with vitamin E protects cells against the toxic effects of oxidative stress. This review briefly summarizes the role of these mitochondrial events in toxic oxidative stress, including: 1) the protective role of mitochondrial vitamin E in toxic oxidative stress, 2) the role of mitochondrial DNA in toxic oxidative stress, 3) the interaction between cardiolipin and cytochrome c in mitochondrial regulation of apoptosis, 4) the role of mitochondrial aconitase in oxidative neurodegeneration, and 5) the role of mitochondrial uncoupling protein 2 in the pathogenesis of type 2 diabetes.
- Date created
- License information
- Attribution-NonCommercial-NoDerivs 3.0 Unported
- Citation for previous publication
Fariss, M. W., Chan, C. B., Patel, M., van Houten, B., & Orrenius, S. (2005). Role of mitochondria in toxic oxidative stress. Molecular Interventions, 5(2), 94-111. http://dx.doi.org/10.1124/mi.5.2.7
- Link to related item
- Date Uploaded
- Date Modified
- Audit Status
- Audits have not yet been run on this file.
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 995987
Last modified: 2017:09:06 16:31:58-06:00
Original checksum: 849ccdb4eeeed26bdfa3cf59f2b3d6e5
Well formed: true
File title: MI_Apr_05_Vol5_No2.indd
File author: megan
Page count: 18