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Permanent link (DOI): https://doi.org/10.7939/R3S46HK7V

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Role of mitochondria in toxic oxidative stress Open Access

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Author or creator
Fariss, M. W.
Chan, C. B.
Patel, M.
van Houten, B.
Orrenius, S.
Additional contributors
Subject/Keyword
Vitamin E/Metabolism
Diabetes Mellitus, Type 2/Metabolism
DNA, Mitochondrial/Metabolism
Humans
Oxygen/Metabolism
Mitochondrial Proteins
Mitochondria/Drug effects
Aconitate Hydratase/Metabolism
Cell Death
Reactive Oxygen Species
Dose-Response Relationship, Drug
Cytochromes c/Metabolism
Phosphorylation
Animals
Oxidative Stress
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Oxidative stress and mitochondrial oxidative damage have been implicated in the etiology of numerous common diseases. The critical mitochondrial events responsible for oxidative stress–mediated cell death (toxic oxidative stress), however, have yet to be defined. Several oxidative events implicated in toxic oxidative stress include alterations in mitochondrial lipids (e.g., cardiolipin), mitochondrial DNA, and mitochondrial proteins (eg. aconitase and uncoupling protein 2). Furthermore, recent findings indicate the enrichment of mitochondrial membranes with vitamin E protects cells against the toxic effects of oxidative stress. This review briefly summarizes the role of these mitochondrial events in toxic oxidative stress, including: 1) the protective role of mitochondrial vitamin E in toxic oxidative stress, 2) the role of mitochondrial DNA in toxic oxidative stress, 3) the interaction between cardiolipin and cytochrome c in mitochondrial regulation of apoptosis, 4) the role of mitochondrial aconitase in oxidative neurodegeneration, and 5) the role of mitochondrial uncoupling protein 2 in the pathogenesis of type 2 diabetes.
Date created
2005
DOI
doi:10.7939/R3S46HK7V
License information

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Attribution-NonCommercial-NoDerivs 3.0 Unported
Citation for previous publication
Fariss, M. W., Chan, C. B., Patel, M., van Houten, B., & Orrenius, S. (2005). Role of mitochondria in toxic oxidative stress. Molecular Interventions, 5(2), 94-111.  http://dx.doi.org/10.1124/mi.5.2.7

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