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Permanent link (DOI): https://doi.org/10.7939/R3TQ29

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Longitudinal Associations of Genetic Polymorphisms and Personality Traits: Independent and Interactive Effects on Neurocognitive Performance in Older Adults Open Access

Descriptions

Other title
Subject/Keyword
gene x gene interactions
personality traits
neurocognition
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Sapkota, Shraddha
Supervisor and department
Dixon, Roger (Psychology)
Examining committee member and department
Camicioli, Richard (Neurology)
Wiebe, Sandra (Psychology)
Fujiwara, Esther (Psychiatry)
Department
Centre for Neuroscience
Specialization

Date accepted
2013-09-26T07:55:47Z
Graduation date
2013-11
Degree
Master of Science
Degree level
Master's
Abstract
Research has linked multifaceted neurocognitive phenotypes to genetic polymorphisms and environmental factors. This study examines associations of personality traits and single nucleotide polymorphisms (SNPs) on cognition. Structural equation modeling was used to examine (a) independent and interactive effects of six SNPs (APOE, COMT, BDNF, CLU, CR1, PICALM) and (b) five personality traits on (c) cognitive performance and change in (d) a five-wave (approximately 14-years) longitudinal sample of older adults (N=282). We observed (a) adults with high openness levels performed higher on memory and neurocognitive speed, (b) COMT allelic risk carriers showed shallower positive slope and BDNF allelic risk carriers had steeper change in memory, (c) combined allelic risk group for APOExCR1 had the worst performance on vocabulary and APOExCOMT and APOExBDNF groups had shallower positive change on word recall, and (d) neuroticism levels moderated memory performance for CLU and COMT in the unexpected directions. Implications of findings are discussed.
Language
English
DOI
doi:10.7939/R3TQ29
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File title: Genetic and Personality Associations with
File author: Shraddha Sapkota
Page count: 113
File language: en-US
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