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Organization of the cerebellum: correlating biochemistry, physiology and anatomy in the ventral uvula of pigeons Open Access


Other title
Acoustic nerve -- Animal models
Cerebellum -- Animal models
Uvula -- Animal models
Cerebellar cortex -- Research
Pigeons -- Physiology
Motion perception (Vision) -- Molecular aspects
Type of item
Degree grantor
University of Alberta
Author or creator
Graham, David
Supervisor and department
Wylie, Douglas (Psychology)
Examining committee member and department
Fouad, Karim (Rehabilitation Medicine)
Treit, Dallas (Psychology)
Centre for Neuroscience

Date accepted
Graduation date
Master of Science
Degree level
The fundamental unit of organization in the cerebellum is the parasagittal zone, which can be seen in anatomical connections, physiological response properties, and molecular composition. This parasagittal arrangement is evolutionarily conserved and appears necessary for information processing. However, the relationship between these parasagittal zones and cerebellar function remains unclear. The goal of this thesis is to relate the zonal organization of various features involved in visual motion processing in the vestibulocerebellum by using immunochemical, electrophysiological and neuroanatomical techniques. Zebrin II (aldolase C) is heterogeneously expressed by Purkinje cells in alternating sagittal stripes of high and low (or no) expression. We demonstrate a clear relationship between zebrin II stripes, Purkinje cell response properties, and the visual climbing fibre afferents to the medial vestibulocerebellum. By examining the molecular, anatomical and physiological basis of parasagittal zones, we can uncover the basic principle of organization and function of the cerebellum.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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