ERA

Download the full-sized PDF of Systematic review of safety and tolerability of a complex micronutrient formula used in mental healthDownload the full-sized PDF

Analytics

Share

Permanent link (DOI): https://doi.org/10.7939/R3H98ZS7X

Download

Export to: EndNote  |  Zotero  |  Mendeley

Communities

This file is in the following communities:

Agricultural, Food and Nutritional Science, Department of

Collections

This file is in the following collections:

Journal Articles (Agricultural, Food and Nutritional Science)

Systematic review of safety and tolerability of a complex micronutrient formula used in mental health Open Access

Descriptions

Author or creator
Simpson, J. Steven A.
Crawford, Susan G.
Goldstein, Estelle T.
Field, Catherine J.
Burgess, Ellen
Kaplan, Bonnie J.
Additional contributors
Subject/Keyword
Behavior
Mood
Mineral Supplement
Bipolar Disorder
Young-Adult Prisoners
Double-Blind
Placebo-Controlled Trial
Children
Multivitamin
Vitamins
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Background Theoretically, consumption of complex, multinutrient formulations of vitamins and minerals should be safe, as most preparations contain primarily the nutrients that have been in the human diet for millennia, and at safe levels as defined by the Dietary Reference Intakes. However, the safety profile of commercial formulae may differ from foods because of the amounts and combinations of nutrients they contain. As these complex formulae are being studied and used clinically with increasing frequency, there is a need for direct evaluation of safety and tolerability. Methods All known safety and tolerability data collected on one complex nutrient formula was compiled and evaluated. Results Data were assembled from all the known published and unpublished studies for the complex formula with the largest amount of published research in mental health. Biological safety data from 144 children and adults were available from six sources: there were no occurrences of clinically meaningful negative outcomes/effects or abnormal blood tests that could be attributed to toxicity. Adverse event (AE) information from 157 children and adults was available from six studies employing the current version of this formula, and only minor, transitory reports of headache and nausea emerged. Only one of the studies permitted a direct comparison between micronutrient treatment and medication: none of the 88 pediatric and adult participants had any clinically meaningful abnormal laboratory values, but tolerability data in the group treated with micronutrients revealed significantly fewer AEs and less weight gain. Conclusions This compilation of safety and tolerability data is reassuring with respect to the broad spectrum approach that employs complex nutrient formulae as a primary treatment.
Date created
2011
DOI
doi:10.7939/R3H98ZS7X
License information

Rights
Attribution 4.0 International
Citation for previous publication
Simpson, J. S. A., Crawford, S. G., Goldstein, E. T., Field, C. J., Burgess, E., & Kaplan, B. J. (2011). Systematic review of safety and tolerability of a complex micronutrient formula used in mental health. BMC Psychiatry, 11(62), [7 pages].  http://dx.doi.org/10.1186/1471-244X-11-62

Source

Link to related item

File Details

Date Uploaded
Date Modified
Audit Status
Audits have not yet been run on this file.
Characterization
File format: pdf (PDF/A)
Mime type: application/pdf
File size: 321403
Last modified: 2017:09:06 16:14:55-06:00
Filename: BMCPsych_11_62.pdf
Original checksum: 38348b90850425270237a2f5a35ec743
Copyright note: © 2011 Simpson et al; licensee BioMed Central Ltd.
Activity of users you follow
User Activity Date