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Permanent link (DOI): https://doi.org/10.7939/R3C824T7K

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Formulating food protein-stabilized indomethacin nanosuspensions into pellets by fluid-bed coating technology: Physical characterization, redispersibility, and dissolution Open Access

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Author or creator
He, Wei
Lu, Yi
Qi, Jianping
Chen, Lingyun
Yin, Lifang
Wu, Wei
Additional contributors
Subject/Keyword
Fluid-Bed Coating
Poorly Water-Soluble Drugs
Indomethacin
Nanocrystals
Food Proteins
Nanosuspensions
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Background: Drug nanosuspensions are very promising for enhancing the dissolution and bioavailability of drugs that are poorly soluble in water. However, the poor stability of nanosuspensions, reflected in particle growth, aggregation/agglomeration, and change in crystallinity state greatly limits their applications. Solidification of nanosuspensions is an ideal strategy for addressing this problem. Hence, the present work aimed to convert drug nanosuspensions into pellets using fluid-bed coating technology. Methods: Indomethacin nanosuspensions were prepared by the precipitation-ultrasonication method using food proteins (soybean protein isolate, whey protein isolate, ß-lactoglobulin) as stabilizers. Dried nanosuspensions were prepared by coating the nanosuspensions onto pellets. The redispersibility, drug dissolution, solid-state forms, and morphology of the dried nanosuspensions were evaluated. Results: The mean particle size for the nanosuspensions stabilized using soybean protein isolate, whey protein isolate, and β-lactoglobulin was 588 nm, 320 nm, and 243 nm, respectively. The nanosuspensions could be successfully layered onto pellets with high coating efficiency. Both the dried nanosuspensions and nanosuspensions in their original amorphous state and not influenced by the fluid-bed coating drying process could be redispersed in water, maintaining their original particle size and size distribution. Both the dried nanosuspensions and the original drug nanosuspensions showed similar dissolution profiles, which were both much faster than that of the raw crystals. Conclusion: Fluid-bed coating technology has potential for use in the solidification of drug nanosuspensions.
Date created
2013
DOI
doi:10.7939/R3C824T7K
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Attribution-NonCommercial 4.0 International
Citation for previous publication
He, W., Lu, Y., Qi, J., Chen, L., Yin, L., & Wu, W. (2013). Formulating food protein-stabilized indomethacin nanosuspensions into pellets by fluid-bed coating technology: Physical characterization, redispersibility, and dissolution. International Journal of Nanomedicine, 8(1), 3119-3128.  https://dx.doi.org/10.2147/IJN.S46207

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