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Permanent link (DOI): https://doi.org/10.7939/R3HT2GR82

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The BETA-2 Score: a Tool for Assessing Beta Cell Function in Clinical Islet Transplantation and Type 1 Diabetes Intervention Trials Open Access

Descriptions

Other title
Subject/Keyword
Beta cell function
Type 1 Diabetes
BETA-2 score
Islet Transplantation
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Lam, Anna
Supervisor and department
Senior, Peter (Medicine)
Examining committee member and department
MacDonald, Patrick (Pharmacology)
Rosolowsky, Elizabeth (Pediatrics)
Eurich, Dean (School of Public Health)
Department
Department of Medicine
Specialization

Date accepted
2017-09-27T13:22:53Z
Graduation date
2017-11:Fall 2017
Degree
Master of Science
Degree level
Master's
Abstract
Preservation of beta cell function is integral to clinical islet transplantation (CIT) and in the development of treatments which halt the progression of type 1 diabetes (T1D). Outcome assessment remains difficult in both fields as the preservation of beta cell function and maintenance of glucose homeostasis must be considered. Stimulated C-peptide is the gold standard for measuring beta cell function, but it is time and labor intensive to measure. Insulin use and measures of glycemic control are inter-dependent and alone are unlikely to capture changes in beta cell function. The BETA-2 score was developed in CIT as a practical measure of beta cell function that also provides information on overall metabolic status. I demonstrate here the utility of the BETA-2 score in assessing islet engraftment in CIT. I also explore the use of the BETA-2 score as a clinical endpoint in T1D intervention trials.
Language
English
DOI
doi:10.7939/R3HT2GR82
Rights
This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for the purpose of private, scholarly or scientific research. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
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