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Permanent link (DOI): https://doi.org/10.7939/R3QM0K

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Hippocampal neuroplasticity and neurogenesis in major depressive disorder: a high field MRI study Open Access

Descriptions

Other title
Subject/Keyword
MDD
stress
magnetic resonance imaging
subfield
cornu ammonis
neurogenesis
major depressive disorder
brain
dentate gyrus
subiculum
hypothalamic-pituitary-adrenal
HPA
neuroplasticity
volume
hippocampus
subregion
MRI
depression
intracranial
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Huang, Yushan Yu Xiang
Supervisor and department
Malykhin, Nikolai (Biomedical Engineering)
Baker, Glen (Psychiatry)
Examining committee member and department
Wilman, Alan (Biomedical Engineering)
Baker, Glen (Psychiatry)
Malykhin, Nikolai (Biomedical Engineering)
Department
Centre for Neuroscience
Specialization

Date accepted
2012-09-28T09:38:19Z
Graduation date
2012-09
Degree
Master of Science
Degree level
Master's
Abstract
The hippocampus is a brain structure responsible for memory, learning, and the stress response; it is also used as a model for major depressive disorder (MDD) in preclinical studies. Preclinical models have shown that the hippocampal subfields are differentially affected by chronic stress. Studies using magnetic resonance imaging (MRI) have shown reductions in hippocampal volumes MDD. With the high-field 4.7 Tesla MRI, we have for the first time analyzed the hippocampal subfields in vivo in patients with MDD and healthy controls. Our data suggest that MDD patients had smaller volumes of the cornu ammonis (CA) and dentate gyrus (DG) subfields of the hippocampus, which contributed to an overall reduction in the total volume of the hippocampus and its subregions. Our results also suggested that antidepressant treatment might reverse these volumetric reductions in the CA and DG subfields as suggested previously in preclinical studies.
Language
English
DOI
doi:10.7939/R3QM0K
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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