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A genome-wide association study of fetal response to type 2 porcine reproductive and respiratory syndrome virus challenge Open Access

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Author or creator
Yang, Tianfu
Wilkinson, James
Wang, Zhiquan
Ladinig, Andrea
Harding, John
Plastow, Graham
Additional contributors
Subject/Keyword
Genome-Wide Association Studies
Viral Infection
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Control of porcine reproductive and respiratory syndrome (PRRS) is economically important for the swine industry worldwide. As current PRRS vaccines do not completely protect against heterologous challenge, alternative means of control, including enhanced genetic resilience, are needed. For reproductive PRRS, the genetic basis of fetal response to PRRS virus (PRRSV) infection is poorly understood. Genome-wide association studies (GWAS) were done here using data from 928 fetuses from pregnant gilts experimentally challenged with type 2 PRRSV. Fetuses were assessed for viral load in thymus (VLT), viral load in endometrium (VLE), fetal death (FD) and fetal viability (FV), and genotyped at a medium density. Collectively, 21 candidate genomic regions were found associated with these traits, seven of which overlap with previously reported QTLs for pig health and reproduction. A comparison with ongoing and related transcriptomic analyses of fetal response to PRRSV infection found differentially expressed genes within 18 candidate regions. Some of these genes have immune system functions, and have been reported to contribute to host response to PRRSV infection. The results provide new evidence about the genetic basis of fetal response to PRRSV challenge, and may ultimately lead to alternative control strategies to reduce the impact of reproductive PRRS.
Date created
2016/02/05
DOI
doi:10.7939/R37F6S
License information
Attribution 4.0 International
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Citation for previous publication
Yang, T., Wilkinson, J., Wang, Z., Ladinig, A., Harding, J., Plastow, G. (2016) A genome-wide association study of fetal response to type 2 porcine reproductive and respiratory syndrome virus challenge. Scientific Reports 6: 20305 doi: 10.1038/srep20305
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2016-06-07T16:47:07.965+00:00
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Last modified: 2016:06:07 10:47:13-06:00
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Copyright note: © 2016 Nature Publishing Group
File title: A genome-wide association study of fetal response to type 2 porcine reproductive and respiratory syndrome virus challenge
File author: Tianfu Yang
Page count: 14
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