Download the full-sized PDF of Short-term Calorie Restriction Improves Post-ischemic Recovery in the Spontaneously Hypertensive RatDownload the full-sized PDF



Permanent link (DOI):


Export to: EndNote  |  Zotero  |  Mendeley


This file is in the following communities:

Graduate Studies and Research, Faculty of


This file is in the following collections:

Theses and Dissertations

Short-term Calorie Restriction Improves Post-ischemic Recovery in the Spontaneously Hypertensive Rat Open Access


Other title
Cardiac Metabolism
Ischemic Preconditioning
Ischemia-Reperfusion Injury
Post-ischemic Recovery
Cardiac Preconditioning
Calorie Restriction
Cardiac Energy Metabolism
Spontaneously Hypertensive Rat
Type of item
Degree grantor
University of Alberta
Author or creator
Lozyk, Mira D
Supervisor and department
Jason Dyck - Pharmacology/Pediatrics
Examining committee member and department
Shairaz Baksh - Pediatrics
Peter Light - Pharmacology
Department of Pharmacology

Date accepted
Graduation date
Master of Science
Degree level
Ischemic heart disease is the leading cause of death in Western countries. We demonstrated how alterations in energy metabolism and the activation of Reperfusion Injury Salvage Kinase (RISK) pathway induced by short-term calorie restriction (CR) contribute to protecting the diseased heart from ischemia/reperfusion (I/R) injury. Our findings using the Spontaneously Hypertensive Rat (SHR) validate that short-term CR exhibits cardioprotection in the rat model of hypertension and cardiac hypertrophy. Our data also suggest that improving glucose oxidation at the time of reperfusion and activating two members of the pro-survival anti-apoptotic RISK pathway, Akt and Erk1/2 MAPK, are possible mechanism by which short-term CR contributes to improving mechanical recovery of the heart during reperfusion following ischemia. Additionally, our data suggest that the effects of short-term CR in I/R injury may be mediated by an AMPK-independent mechanism as the hearts from SHRs exhibited improved metabolic status in presence of significantly reduced AMPK activity.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication

File Details

Date Uploaded
Date Modified
Audit Status
Audits have not yet been run on this file.
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 2289113
Last modified: 2015:10:12 11:52:38-06:00
Filename: Lozyk_Mira_Fall 2012.pdf
Original checksum: 80217fa926c2a6669e9247e53f577f3c
Well formed: false
Valid: false
Status message: Invalid page tree node offset=1626727
Status message: Unexpected error in findFonts java.lang.ClassCastException: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject cannot be cast to edu.harvard.hul.ois.jhove.module.pdf.PdfDictionary offset=2833
Status message: Outlines contain recursive references.
File title: 1_Title Page
Page count: 79
Activity of users you follow
User Activity Date