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Permanent link (DOI): https://doi.org/10.7939/R3MS8D

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Short-term Calorie Restriction Improves Post-ischemic Recovery in the Spontaneously Hypertensive Rat Open Access

Descriptions

Other title
Subject/Keyword
Cardiac Metabolism
Ischemic Preconditioning
Ischemia-Reperfusion Injury
Post-ischemic Recovery
Cardiac Preconditioning
Calorie Restriction
Cardiac Energy Metabolism
Spontaneously Hypertensive Rat
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Lozyk, Mira D
Supervisor and department
Jason Dyck - Pharmacology/Pediatrics
Examining committee member and department
Shairaz Baksh - Pediatrics
Peter Light - Pharmacology
Department
Department of Pharmacology
Specialization

Date accepted
2012-08-08T14:00:16Z
Graduation date
2012-11
Degree
Master of Science
Degree level
Master's
Abstract
Ischemic heart disease is the leading cause of death in Western countries. We demonstrated how alterations in energy metabolism and the activation of Reperfusion Injury Salvage Kinase (RISK) pathway induced by short-term calorie restriction (CR) contribute to protecting the diseased heart from ischemia/reperfusion (I/R) injury. Our findings using the Spontaneously Hypertensive Rat (SHR) validate that short-term CR exhibits cardioprotection in the rat model of hypertension and cardiac hypertrophy. Our data also suggest that improving glucose oxidation at the time of reperfusion and activating two members of the pro-survival anti-apoptotic RISK pathway, Akt and Erk1/2 MAPK, are possible mechanism by which short-term CR contributes to improving mechanical recovery of the heart during reperfusion following ischemia. Additionally, our data suggest that the effects of short-term CR in I/R injury may be mediated by an AMPK-independent mechanism as the hearts from SHRs exhibited improved metabolic status in presence of significantly reduced AMPK activity.
Language
English
DOI
doi:10.7939/R3MS8D
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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