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Optimization of sodium MRI for the human knee at 4.7 tesla Open Access

Descriptions

Other title
Subject/Keyword
osteoarthritis
Sodium
knee
human
MRI
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Watts, Alexander John
Supervisor and department
Zemp, Roger (Electrical and Computer Engineering)
Beaulieu, Christian (Biomedical Engineering)
Examining committee member and department
Lambert, Robert (Radiology, University of Alberta Hospital)
Thompson, Richard (Biomedical Engineering)
Department
Department of Biomedical Engineering, Department of Electrical and Computer Engineering
Specialization

Date accepted
2010-09-22T20:21:37Z
Graduation date
2010-11
Degree
Master of Science
Degree level
Master's
Abstract
Osteoarthritis is characterized by pain and inflammation in joints, typically weight-bearing joints such as the knee. An early warning sign of osteoarthritis is the loss of proteoglycan molecules in the cartilage matrix. A surrogate method for measuring proteoglycan loss is detection of sodium ions, which ionically bond to negatively charged glycosaminoglycan side chains. Sodium MRI has the potential to non-invasively measure proteoglycan content, and hence act as a diagnostic tool for osteoarthritis. However, as sodium MRI suffers from low sodium concentrations in vivo and reduced MR sensitivity compared to standard proton MRI, techniques are required which optimize signal. This thesis examines the hardware, software, and acquisition techniques required in order to achieve high resolution, excellent quality sodium MR images of the human knee in vivo, which has potential applications in early diagnosis as well as pharmacological treatment evaluations of osteoarthritis.
Language
English
Rights
License granted by Alexander Watts (ander@ualberta.ca) on 2010-09-20T18:15:31Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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