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Permanent link (DOI): https://doi.org/10.7939/R3PF8K

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Bioinformatic analyses in early host response to Porcine Reproductive and Respiratory Syndrome virus PRRSV reveals pathway differences between pigs with alternate genotypes for a major host response QTL Open Access

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Author or creator
Schroyen, Martine
Eisley, Christopher
Koltes, James E.
Fritz-Waters, Eric
Choi, Igseo
Plastow, Graham S.
Guan, Le L.
Stothard, Paul
Bao, Hua
Kommadath, Arun
Reecy, James M.
Lunney, Joan K.
Rowland, Robert R.R.
Dekkers, Jack C.M.
Tuggle, Christopher K.
Additional contributors
Subject/Keyword
Pig
PRRS Virus
RNA-Seq
WUR
GBP5
Ion Transport
Homeostasis
Regulatory Factors
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Background A region on Sus scrofa chromosome 4 (SSC4) surrounding single nucleotide polymorphism (SNP) marker WUR10000125 (WUR) has been reported to be strongly associated with both weight gain and serum viremia in pigs after infection with PRRS virus (PRRSV). A proposed causal mutation in the guanylate binding protein 5 gene (GBP5) is predicted to truncate the encoded protein. To investigate transcriptional differences between WUR genotypes in early host response to PRRSV infection, an RNA-seq experiment was performed on globin depleted whole blood RNA collected on 0, 4, 7, 10 and 14 days post-infection (dpi) from eight littermate pairs with one AB (favorable) and one AA (unfavorable) WUR genotype animal per litter. Results Gene Ontology (GO) enrichment analysis of transcripts that were differentially expressed (DE) between dpi across both genotypes revealed an inflammatory response for all dpi when compared to day 0. However, at the early time points of 4 and 7dpi, several GO terms had higher enrichment scores compared to later dpi, including inflammatory response (p 
Date created
2016/03/08
DOI
doi:10.7939/R3PF8K
License information
Attribution 4.0 International
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Citation for previous publication
Schroyen, M., Eisley, C., Koltes, J.E., Fritz-Waters, E., Choi, I., Plastow, G., Guan, L., Stothard, P., Bao, H., Kommadath, A., Reecy, J.M., Lunney, J.K., Rowland, R.R.R., Dekkers, J.C.M., Tuggle, C.K. (2016) Bioinformatic analyses in early host response to Porcine Reproductive and Respiratory Syndrome virus PRRSV reveals pathway differences between pigs with alternate genotypes for a major host response QTL. BMC Genomics 17(196). doi: 10.1186/s12864-016-2547-z
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File title: Abstract
File title: Bioinformatic analyses in early host response to Porcine Reproductive and Respiratory Syndrome virus (PRRSV) reveals pathway differences between pigs with alternate genotypes for a major host response QTL
File author: Martine Schroyen
Page count: 16
File language: EN
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