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Development of Engineered Micro-Particles via Spray Drying for Respiratory Drug Delivery Open Access


Other title
Spray Drying
D-Amino Acids
Respiratory Drug Delivery
Type of item
Degree grantor
University of Alberta
Author or creator
Matinkhoo, Sadaf
Supervisor and department
Dr. Reinhard Vehring, Department of Mechanical Engineering
Examining committee member and department
Dr. Aloke Kumar, Department of Mechanical Engineering
Dr. Warren H. Finlay, Department of Mechanical Engineering
Department of Mechanical Engineering

Date accepted
Graduation date
Master of Science
Degree level
In this study, respirable dry powders for the treatment of Pseudomonas aeruginosa and Burkholderia cepacia complex infections in cystic fibrosis patients were developed. The feasibility of spray drying aqueous solutions containing bacteriophages was investigated. Bacteriophages KS4-M, KS14 and ФKZ/D3 cocktail (active against P. aeruginosa or Burkholderia cepacia) were spray dried in solutions containing other excipients including trehalose and L-leucine. Acceptable process loss (0.4-0.8 log pfu), high delivery efficiency (69.7% of capsule load for the lead formulation), and desirable particle size (2.5-2.8 μm MMAD) were achieved. Then, L-leucine was substituted by and tested against D-leucine in the lead formulation to help eradicate bacteria biofilms. Similar morphologies and MMADs (3.25±0.03 μm and 3.82±0.04 μm for D- and L-leucine/trehalose) were achieved. Both formulations had acceptable total lung mass fractions (62.0±7.81% and 63.66±16.37% of emitted mass for D- and L-leucine/trehalose). Substitution L-leucine with D-leucine was found to be feasible.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
S. Matinkhoo, K. H. Lynch, J. J. Dennis, W. H. Finlay, and R. Vehring, “Spray-dried respirable powders containing bacteriophages for the treatment of pulmonary infections,” Journal of Pharmaceutical Sciences, vol. 100, no. 12, pp. 5197–5205, 2011.

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