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An Investigation of the Oxidation of Carbohydrate versus Fat for Energy in Individuals with Type 2 Diabetes Open Access


Other title
fat oxidizer
carbohydrate oxidizer
24 hour respiratory quotient
type 2 diabetes
Type of item
Degree grantor
University of Alberta
Author or creator
Loehr, Sarah A
Supervisor and department
McCargar, Linda (Agricultural, Food, and Nutritional Science)
Examining committee member and department
Vine, Donna (Agricultural, Food, and Nutritional Science)
Bell, Rhonda (Agricultural, Food, and Nutritional Science)
Bell, Gordon (Physical Education and Recreation)
Department of Agricultural, Food, and Nutritional Science
Nutrition and Metabolism
Date accepted
Graduation date
Master of Science
Degree level
Impaired fat oxidation has been associated with increased plasma free fatty acid concentrations, ectopic fat deposition and insulin resistance, which may contribute to the development of Type 2 Diabetes (T2D). The objectives of this research were to determine whether individuals with T2D oxidized a greater proportion of carbohydrate (CHO oxidizers) versus fat (fat oxidizers) over a 24 hour period, measured by the cumulative respiratory quotient (RQ24), and to identify differences in metabolic variables between CHO and fat oxidizers. Ten participants spent two non-consecutive days in the Whole Body Calorimetry Unit to determine their RQ24. More (n=7) were classified as CHO oxidizers than fat oxidizers (n=3); and CHO oxidizers had a greater central fat distribution (P=0.041) and a higher resting systolic blood pressure (P=0.031) than fat oxidizers. Results of this pilot study suggest that differences in substrate oxidation exist in people with T2D and these differences may be clinically important.
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