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Permanent link (DOI): https://doi.org/10.7939/R3T43JB3C

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An Investigation of the Oxidation of Carbohydrate versus Fat for Energy in Individuals with Type 2 Diabetes Open Access

Descriptions

Other title
Subject/Keyword
fat oxidizer
carbohydrate oxidizer
24 hour respiratory quotient
type 2 diabetes
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Loehr, Sarah A
Supervisor and department
McCargar, Linda (Agricultural, Food, and Nutritional Science)
Examining committee member and department
Vine, Donna (Agricultural, Food, and Nutritional Science)
Bell, Rhonda (Agricultural, Food, and Nutritional Science)
Bell, Gordon (Physical Education and Recreation)
Department
Department of Agricultural, Food, and Nutritional Science
Specialization
Nutrition and Metabolism
Date accepted
2013-08-26T16:07:02Z
Graduation date
2013-11
Degree
Master of Science
Degree level
Master's
Abstract
Impaired fat oxidation has been associated with increased plasma free fatty acid concentrations, ectopic fat deposition and insulin resistance, which may contribute to the development of Type 2 Diabetes (T2D). The objectives of this research were to determine whether individuals with T2D oxidized a greater proportion of carbohydrate (CHO oxidizers) versus fat (fat oxidizers) over a 24 hour period, measured by the cumulative respiratory quotient (RQ24), and to identify differences in metabolic variables between CHO and fat oxidizers. Ten participants spent two non-consecutive days in the Whole Body Calorimetry Unit to determine their RQ24. More (n=7) were classified as CHO oxidizers than fat oxidizers (n=3); and CHO oxidizers had a greater central fat distribution (P=0.041) and a higher resting systolic blood pressure (P=0.031) than fat oxidizers. Results of this pilot study suggest that differences in substrate oxidation exist in people with T2D and these differences may be clinically important.
Language
English
DOI
doi:10.7939/R3T43JB3C
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File format: pdf (Portable Document Format)
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File title: University of Alberta
File author: Sarah Loehr
Page count: 169
File language: en-US
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