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Primary structure of a novel gonadotropin-releasing hormone (GnRH) in the brain of a teleost, Pejerrey Open Access

Descriptions

Author or creator
Montaner, A.D.
Park, M.K.
Fischer, W.H.
Craig, A.G.
Chang, J.P.
Somoza, G.M.
Rivier, J.E.
Sherwood, N.M.
Additional contributors
Subject/Keyword
pituitary-gland
in-vitro
odonthesthes bonariensis
lamprey brain
growth-hormone
chicken GNRH-II
3 forms
Hydrochaeris-Hydrochaeris Mammalia
molecular-forms
carassius-auratus
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
The neuropeptide GnRH is the major regulator of reproduction in vertebrates acting as a first signal from the hypothalamus to pituitary gonadotropes. Three GnRH molecular variants were detected in the brain of a fish, pejerrey (Odontesthes bonariensis), using chromatographic and immunological methods. The present study shows that one form is identical to chicken GnRH-II (sequence analysis and mass spectrometry) and the second one is immunologically and chromatographically similar to salmon GnRH. The third form was proven to be a novel form of GnRH by isolating the peptide from the brain and determining its primary structure by chemical sequencing and mass spectrometry. The sequence of the novel pejerrey GnRH is pGlu-His- Trp-Ser-Phe-Gly-Leu-Ser-Pro-Gly-NH2, which is different from the known forms of the vertebrate and protochordate GnRH family. The new form of GnRH is biologically active in releasing gonadotropin and GH from pituitary cells in an in vitro assay.
Date created
2001
License information
Rights
Copyright © 2001 by The Endocrine Society
Citation for previous publication
Montaner,A.D., Park, M.K.,Fischer, W.H., Craig A.G., Chang, J.P., Somoza, G.M., Rivier, J.E. and Sherwood, N.M. "Primary structure of a novel gonadotropin-releasing hormone (GnRH) in the brain of a teleost, Pejerrey." Endocrinology 142 (2001): 1453-1460.
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