Download the full-sized PDF
Permanent link (DOI): https://doi.org/10.7939/R3H12VF8N
This file is in the following communities:
|Biological Sciences, Department of|
This file is in the following collections:
|Journal Articles (Biological Sciences)|
Tumour-stromal interactions: Integrins and cell adhesions as modulators of mammary cell survival and transformation Open Access
- Author or creator
Chrenek, Micah A.
Weaver, Valerie M.
- Additional contributors
mammary epithelial cell
three-dimensional tissue organization
- Type of item
- Journal Article (Published)
Stromal–epithelial interactions modulate mammary epithelial cell (MEC) growth and apoptosis by influencing cell adhesion and tissue organization. Perturbations in the mammary stroma and cell adhesion characterize breast tumors and underlie the altered tissue organization, disrupted tissue homeostasis and enhanced survival phenotype of the disease. Apoptosis resistance likely arises during malignant transformation via genetic and epigenetic modification of cell adhesion pathways induced by a changing tissue microenvironment. Acquisition of adhesion-linked survival networks that enhance MEC viability in the absence of basement membrane interactions probably promote malignant transformation, and may render breast tumors sufficiently resistant to exogenous apoptotic stimuli to generate multidrug resistance.
- Date created
- License information
- © 2001 BioMed Central Ltd.
- Citation for previous publication
Chrenek, M. A., Wong, P., & Weaver, V. M. (2001). Tumour-stromal interactions: Integrins and cell adhesions as modulators of mammary cell survival and transformation. Breast Cancer Research, 3(4), 224-229. BioMed Central. DOI: 10.1186/bcr300
- Link to related item
- Date Uploaded
- Date Modified
- Audit Status
- Audits have not yet been run on this file.
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 158121
Last modified: 2015:10:12 20:43:45-06:00
Original checksum: b66090f99f7d792832a4063b2cf7771a
Well formed: true
Status message: Improperly formed date offset=156976
File title: BCR0304r04_Chrenek.qxd
File author: Neil Morris
Page count: 6