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Left Ventricular Ejection Fraction and Volume Calculations Using Three-Dimensional Echocardiography Open Access


Other title
Ejection fraction
LV volumes
LV normal values
3D echocardiography
Left ventricular function
Type of item
Degree grantor
University of Alberta
Author or creator
Wood, Peter William
Supervisor and department
Becher, Harald (Medicine)
Examining committee member and department
Becher, Harald (Medicine)
Choy, Jonathan (Medicine)
Raggi, Paolo (Medicine)
Haennell, Rober (Rehabilitation Medicine)
Department of Medicine
Experimental Medicine
Date accepted
Graduation date
Master of Science
Degree level
In a review encompassing 18 single- and multi-centre studies comparing echocardiography with magnetic resonance imaging, it was determined that three-dimensional echocardiography has greatly improved the calculation of left ventricular (LV) volumes. However, there is still a systematic underestimation of volume measurements, and experimental studies have yet to be performed. This project sought to assess the accuracy of current semi-automatic contour finding algorithms using an anatomically correct dynamic heart phantom. The contour algorithm resulted in an underestimation of up to 31% of the true volume. With manual correction this reduced to 21%. None of the semi-automatic contours followed completely the true ventricular border. The manual method of discs (MOD) technique was proposed as a method which may improve accuracy in patients with asymmetric ventricles; the largest difference was 9% of the true volume. Therefore, while currently available LV contouring algorithms further underestimate volumes in asymmetrical chambers, MOD is an accurate alternative.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Wood PW, Choy JB, Nanda NC, Becher H. Left Ventricular Ejection Fraction: It Depends On The Imaging Method. Echocard 2013;In Press.

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