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Permanent link (DOI): https://doi.org/10.7939/R3406C

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Effects of Hyperthermia and Subsequent Minocycline Treatment in Acute Ischemic Stroke Open Access

Descriptions

Other title
Subject/Keyword
hyperthermia
stroke
laminin
matrix metalloprotease
ischemia
minocycline
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Rahman, Shakib Hafizur
Supervisor and department
Todd, Kathryn G (Center for Neuroscience)
Shuaib, Ashfaq (Neurology)
Examining committee member and department
Shuaib, Ashfaq (Neurology)
Winship, Ian (Psychiatry)
Todd, Kathryn G (Center for Neuroscience)
Department
Department of Medicine
Specialization
Experimental Medicine
Date accepted
2012-04-02T09:26:29Z
Graduation date
2012-06
Degree
Master of Science
Degree level
Master's
Abstract
Stroke, a reduction in blood flow to the brain, activates various proteins that contribute to neuronal death. The matrix metalloproteinases (MMPs), specifically MMP2 and MMP9, are important in maintaining the blood brain barrier (BBB). After a stroke the BBB permeability increases which is caused by MMP upregulation. Hyperthermia is known to exacerbate the damage caused by a stroke, but the exact mechanism is unknown. We hypothesize that hyperthermia will increase MMP expression and that minocycline, an MMP inhibitor, will decrease MMP activity and BBB permeability. Our data demonstrates that hyperthermia increases expression of both MMP2 and MMP9. Furthermore, hyperthermia after ischemia increases degradation of laminin. Minocycline can reduce both expression and activity of MMP2 and MMP9 after ischemia. Minocycline is effective in hyperthermic conditions and reduces degradation of laminin. This data shows that minocycline is a potential therapeutic treatment for reducing MMP activity and subsequent laminin degradation after a stroke.
Language
English
DOI
doi:10.7939/R3406C
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Alam M, Mohammad A, Rahman S, Todd K and Shuaib A. Hyperthermia up-regulates matrix metalloproteinases and accelerates basement membrane degradation in experimental stroke. Neuroscience Letters. (2011) May 16;495(2):135-9.

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