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Permanent link (DOI): https://doi.org/10.7939/R38714

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Feeding high oleic acid Canola oil or olive oil alters inflammation, insulin resistance and lipid metabolism in a rodent model of diet induced obesity Open Access

Descriptions

Other title
Subject/Keyword
diabetes
lipid metabolism
inflammation
oleic acid
obesity
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Ruby, Kelsi
Supervisor and department
Field, Catherine (AFNS)
Examining committee member and department
Chan, Catherine (AFNS)
Cameron, Lisa (Medicine)
Department
Department of Agricultural, Food, and Nutritional Science
Specialization

Date accepted
2011-08-29T16:02:52Z
Graduation date
2011-11
Degree
Master of Science
Degree level
Master's
Abstract
To determine the efficacy of feeding monounsaturated fatty acids (MUFA) via a high MUFA Canola oil on T2D risk factors diet induced obese rats were fed either a low fat diet (LF), a high fat low MUFA diet (HF), a high fat high MUFA olive oil diet (OO), or a high fat high MUFA Canola oil diet (HCO) diet for 4 weeks. The effect on immune function, insulin sensitivity and the fatty acid composition of phospholipids (PL) and stored lipids were measured. Increasing MUFA in the diet resulted in a lower (p<0.05) production of pro-inflammatory cytokines compared to HF; however, OO had a greater (p<0.05) effect compared to HCO. Feeding OO led to significantly greater (p<0.05) proportions of oleic and linoleic acid compared to feeding HCO in spleen PL. In summary, dietary MUFA altered lipid metabolism and lowered the pro-inflammatory response; however, HCO and OO were not equivalent. In a diet of similar fatty acid composition, feeding MUFA from OO was more effective in dampening the pro-inflammatory response by immune cells in obese rats.
Language
English
DOI
doi:10.7939/R38714
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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