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Changes in corticospinal excitability induced by neuromuscular electrical stimulation Open Access


Other title
motor cortex
corticospinal excitability
neuromuscular electrical stimulation
stimulation frequency
transcranial magnetic stimulation
Type of item
Degree grantor
University of Alberta
Author or creator
Mang, Cameron Scott
Supervisor and department
Collins, David (Physical Education and Recreation)
Examining committee member and department
Gorassini, Monica (Biomedical Engineering)
Jones, Kelvin (Physical Education and Recreation)
Physical Education and Recreation

Date accepted
Graduation date
Master of Science
Degree level
This thesis describes experiments designed to investigate the effects of neuromuscular electrical stimulation (NMES) on corticospinal (CS) excitability in humans. NMES delivered at 100 Hz was more effective for increasing CS excitability than 10-, 50-, or 200-Hz NMES. CS excitability increases occurred after 24 min of 100-Hz NMES, were strongest in the stimulated muscle, and were mediated primarily at a supraspinal level. NMES of the common peroneal nerve of the leg increased CS excitability in multiple leg muscles, whereas NMES of the median nerve of the hand increased CS excitability in only the muscle innervated by that nerve. Additionally, CS excitability for the hand increased after 40 min of relatively high intensity and frequency NMES but not after 2 h of lower intensity and frequency NMES. These results have implications for identifying optimal NMES parameters to augment CS excitability for rehabilitation after central nervous system injury.
License granted by Cameron Mang ( on 2010-08-30T04:11:09Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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