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Permanent link (DOI): https://doi.org/10.7939/R3ND18

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Chronic Maternal Stress and Genetic Variants in the Etiology of Spontaneous Preterm Birth Open Access

Descriptions

Other title
Subject/Keyword
preterm birth
single nucleotide polymorphisms
chronic maternal stress
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Christiaens, Inge
Supervisor and department
Olson, David (Physiology, Obstetrics and Gynecology, Pediatrics)
Examining committee member and department
Hegadoren, Kathleen (Nursing)
Gravett, Michael (Obstetrics and Gynecology)
Chari, Radha (Obstetrics and Gynecology)
Somerville, Martin (Medical Genetics)
Kassiri, Zam (Physiology)
Department
Department of Physiology
Specialization

Date accepted
2012-08-29T15:58:03Z
Graduation date
2012-11
Degree
Doctor of Philosophy
Degree level
Doctoral
Abstract
Preterm birth is the leading cause of mortality and morbidity in newborn infants. With an estimated 15 million preterm births annually worldwide, the global burden of preterm birth is enormous. Despite decades of research, its etiology remains elusive. Preterm birth is a complex phenomenon with genes and environmental factors contributing to its risk, both in the mother and the fetus. For this dissertation, we explored the role of chronic maternal stress and genetic variants in the etiology of spontaneous preterm birth. We conducted a case-control study in 622 women in Edmonton. First, we examined the association between lifetime chronic stress and preterm birth. Exposure to two or more adverse childhood experiences was associated with a two-fold risk of preterm birth, regardless of maternal age, smoking status, educational status and a history of miscarriage (OR 2.09, p=0.024) Lifetime physical and emotional abuse was also associated with spontaneous preterm in our study population (OR 1.3, p=0.033) Second, we conducted genomic studies for preterm birth in collaboration with the Preterm Birth Genome Project, the World Health Organization and the March of Dimes. Using a candidate gene approach, we discovered two novel single nucleotide polymorphisms (SNPs), both located in the mineralocorticoid receptor gene that associate with spontaneous preterm birth: rs17484063 (OR 0.50, p=0.038) and rs2883929 (OR 0.49, p=0.017). For each additional effect allele, the risk of preterm birth was halved. In women with ≤1 adverse childhood experiences, the odds ratios of rs17484063 and rs2883929 for preterm birth were further lowered (OR 0.37; p=0.024 and OR 0.37; p=0.013, respectively). Via activation of the maternal-fetal HPA axis, a biological plausibility of the role of these SNPs in the etiology of preterm birth exists. This is the first evidence of genetic variations in the mineralocorticoid receptor gene that associate with spontaneous preterm birth. In addition, we discovered a strong relationship between adverse childhood experiences and preterm birth. Taken together, this research confirmed that chronic maternal stress and genes involved in the stress response likely have an impact on the risk of spontaneous preterm birth.
Language
English
DOI
doi:10.7939/R3ND18
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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