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Airborne particulate matter and a western style diet as potential environmental factors in the pathogenesis of Inflammatory Bowel Disease Open Access


Other title
western diet and immune function
environmental factors and Inflammatory bowel disease
mouse model of colitis
particulate matter and immune function
Type of item
Degree grantor
University of Alberta
Author or creator
Kish, Lisa
Supervisor and department
Madsen, Karen (Medicine)
Examining committee member and department
Wine, Eytan (Pediatrics)
Vine, Donna (Agricultural Food and Nutritional Science)
Department of Medicine

Date accepted
Graduation date
Master of Science
Degree level
Inflammatory bowel disease is believed to occure in response to environmental factors resulting in immune dysregulation in genetically predisposed individuals. Such environmental factors include diet, (specifically a “western diet”rich in refined sugars, and fat) and airborne particulate matter (PM) pollution. Normally the gastrointestinal tract maintains tolerance to luminal antigens and the enteric flora, however, it’s proposed that in genetically predisposed individuals, presence of such antigens acts to trigger or exacerbate intestinal inflammation resulting in IBD development. In this thesis, I demonstrate the ability for short-term, oral exposure of PM to initiate an acute intestinal inflammatory response in wild type mice. Next, long term oral PM exposure alters the expression of various Th1/Th2 mediated cytokines microbial composition in WT and IL10-/- mice. Finally, I demonstrate that exposure to a western diet, with or without, PM results in immunosuppression in the colon and significant inflammation in the small intestine of IL10-/- mice.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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