ERA

Download the full-sized PDF of Vasopressin and the Asphyxiated NeonateDownload the full-sized PDF

Analytics

Share

Permanent link (DOI): https://doi.org/10.7939/R3T111

Download

Export to: EndNote  |  Zotero  |  Mendeley

Communities

This file is in the following communities:

Graduate Studies and Research, Faculty of

Collections

This file is in the following collections:

Theses and Dissertations

Vasopressin and the Asphyxiated Neonate Open Access

Descriptions

Other title
Subject/Keyword
Asphyxia
Neonatal
Swine
Dobutamine
Vasopressin
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Pelletier, Jean-Sébastien
Supervisor and department
Cheung, Po-Yin (Pediatrics, Pharmacology)
Bigam, David (Surgery)
Examining committee member and department
Churchill, Tom (Surgery)
Dicken, Bryan (Surgery)
Joynt, Chloe (Pediatrics)
Department
Department of Surgery
Specialization
Experimental Surgery
Date accepted
2013-06-11T09:05:13Z
Graduation date
2013-11
Degree
Master of Science
Degree level
Master's
Abstract
Cardiovascular dysfunction in asphyxiated neonates leads to significant morbidity and mortality and the hemodynamic support is limited to the use of catecholamines. In a pilot study, we showed that low-dose vasopressin improved myocardial tissue lactate levels, suggesting decreased anaerobic metabolism. We postulated that starting this infusion earlier would benefit systemic hemodynamics. The aim was to compare the systemic and regional hemodynamic effects of vasopressin and dobutamine, a synthetic beta-adrenoreceptor agonist commonly used clinically. This study is the first to demonstrate that a low-dose vasopressin infusion used in the setting of a neonatal swine model of hypoxia-reoxygenation improves cardiac output and mesenteric perfusion, with results comparable to those of dobutamine. Improved myocardial biomarkers and evidence of decreased mesenteric oxidative stress confirmed our results. We did not demonstrate a benefit to the combined used of vasopressin and dobutamine. We conclude that low-dose vasopressin may be useful in the treatment of perinatal asphyxia.
Language
English
DOI
doi:10.7939/R3T111
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication

File Details

Date Uploaded
Date Modified
2014-04-25T00:21:30.734+00:00
Audit Status
Audits have not yet been run on this file.
Characterization
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 15214122
Last modified: 2015:10:12 12:34:01-06:00
Filename: Thesis (Final).pdf
Original checksum: 0eef0910be1bb54342271a34fcd14484
Well formed: true
Valid: true
Status message: File header gives version as 1.4, but catalog dictionary gives version as 1.3
File title: Prefatory Pages
File author: Jean-S??bastien Pelletier
File author: Jean-Sbastien Pelletier
Page count: 260
Activity of users you follow
User Activity Date