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Permanent link (DOI): https://doi.org/10.7939/R3MT2G

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Notch regulates the growth-promoting nitric oxide cGMP-dependent pathway in epithelial ovarian cancer and ovarian surface epithelium cells Open Access

Descriptions

Other title
Subject/Keyword
Tumor growth
Notch signaling
Nitric Oxide
GUCY1B3
Solubule guanylate cyclase
Targeted therapy
Epithelial ovarian cancer
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
El-Sehemy, Ahmed Ali Ahmed Ali
Supervisor and department
Shaw, Andrew (Department of Oncology)
Fu, YangXin (Department of Obstetrics & Gynecology, Department of Oncology)
Examining committee member and department
Postovit, Lynne-Marie (Department of Oncology)
Godbout, Roseline (Department of Oncology)
Shaw, Andrew (Department of Oncology)
Underhill, Alan (Department of Oncology)
Fu, YangXin (Department of Obstetrics & Gynecology, Department of Oncology)
Department
Department of Oncology
Specialization
Experimental Oncology
Date accepted
2013-12-13T15:01:27Z
Graduation date
2014-06
Degree
Master of Science
Degree level
Master's
Abstract
Ovarian cancer is the leading cause of mortality among gynecologic cancers. There are several subtypes of ovarian cancer, amongst which epithelial ovarian cancer (EOC) makes up to 90% of all ovarian cancers. The current treatment for EOC consists of debulking surgery followed by a chemotherapeutic regimen composed of platinum-derivative/paclitaxel agents. This regimen is inefficient due to the high rate of chemoresistance development. Thus, targeted therapeutic strategies are in demand in order to control this disease. To this end, a better understanding of the molecular pathways and mechanisms underlying the initiation and development of EOC is required. Here, we report the interaction between the oncogenic Notch and nitric oxide (NO) pathways and provide novel insights into the molecular nature of this interaction. Moreover, we show that NO signaling promotes the growth of EOC cells in vitro and propose blocking this pathway as a potential targeted therapeutic strategy in EOC.
Language
English
DOI
doi:10.7939/R3MT2G
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
El-Sehemy, A. et al. Notch activation augments nitric oxide/soluble guanylyl cyclase signaling in immortalized ovarian surface epithelial cells and ovarian cancer cells. Cell Signal 25, 2780-7 (2013).

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