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Permanent link (DOI): https://doi.org/10.7939/R3VX06D75

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RNA helicases and abiotic stress Open Access

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Author or creator
Owttrim, G.W.
Additional contributors
Subject/Keyword
arabidopsis-thaliana
export factor
dead-box protein
translation initiation-factor
heat-shock
saccharomyces-cerevisiae
length CDNA microarray
cold-shock protein
escherichia-coli
bacillus-subtilis
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
RNA helicases function as molecular motors that rearrange RNA secondary structure, potentially performing roles in any cellular process involving RNA metabolism. Although RNA helicase association with a range of cellular functions is well documented, their importance in response to abiotic stress is only beginning to emerge. This review summarizes the available data on the expression, biochemistry and physiological function(s) of RNA helicases regulated by abiotic stress. Examples originate primarily from non-mammalian organisms while instances from mammalian sources are restricted to post-translational regulation of helicase biochemical activity. Common emerging themes include the requirement of a cold-induced helicase in non-homeothermic organisms, association and regulation of helicase activity by stress-induced phosphorylation cascades, altered nuclear– cytoplasmic shuttling in eukaryotes, association with the transcriptional apparatus and the diversity of biochemical activities catalyzed by a subgroup of stress-induced helicases. The data are placed in the context of a mechanism for RNA helicase involvement in cellular response to abiotic stress. It is proposed that stress-regulated helicases can catalyze a nonlinear, reversible sequence of RNA secondary structure rearrangements which function in RNA maturation or RNA proofreading, providing a mechanism by which helicase activity alters the activation state of target RNAs through regulation of the reaction equilibrium.
Date created
2006
DOI
doi:10.7939/R3VX06D75
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Copyright 2006 The Author(s).
Citation for previous publication
GW Owttrim. "RNA helicases and abiotic stress." Nucleic Acids Research 34 (2006): 3220-3230. DOI: doi:10.1093/nar/gkl408
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