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Permanent link (DOI): https://doi.org/10.7939/R3PQ6K

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Uniaxial Compaction of Pharmaceutical Powders Open Access

Descriptions

Other title
Subject/Keyword
Compressed bulk density
Modulated compaction profile
Densification
Elastic and plastic deformation
Power compaction
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Shamsaddini Shahrbabak, Abouzar
Supervisor and department
Vehring, Reinhard (Mechanical Engineering)
Examining committee member and department
Lobenberg, Raimar (Faculty of pharmacy and pharmaceutical sciences)
Olfert, Jason (Mechanical Engineering)
Department
Department of Mechanical Engineering
Specialization

Date accepted
2013-03-15T15:51:22Z
Graduation date
2013-06
Degree
Master of Science
Degree level
Master's
Abstract
A thorough understanding and precise characterization of powdered excipients and drugs are of great importance to enhance the quality of the final product. Powder compression is a common method to evaluate their properties and behavior. It is essential to understand the elastic, viscoelastic and plastic response of powder to the compression force. A new instrument, the University of Alberta Density Tester, was developed for this purpose. It can be used to measure the Compressed Bulk Density of pharmaceutical powders along with other parameters. A measurement method using low-pressure compaction was implemented. This type of powder characterization method has several advantages. A very small amount of sample is needed which is important when dealing with expensive or scarce samples. Secondly, poorly compactable powders can be analyzed accurately. The importance of the former is evident as powder characterization using traditional methods are restricted by the high amount of sample required. The latter allows analysis of respirable samples where interparticle forces rather than inertial forces become dominant for the compaction behavior. For the same reasons the applicability of the conventional methods like tapped density measurements is questionable. Another advantage of this technique is that the developed instrument is very sensitive and shows significant response to any changes in the testing conditions even if the changes are very slight. Experimental results were fitted to two empirical models, the Heckel and Kawakita models, to evaluate mechanistic behavior of the powders under different levels of compaction. In this study, a novel modulated compaction technique was developed that helps in the interpretation of different compaction stages. Modulated Compression Profiles differentiate between elastic and plastic behavior of powders under compression, which may lead to further development or refinement of compression models that can provide a better understanding of the different compression mechanisms.
Language
English
DOI
doi:10.7939/R3PQ6K
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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