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Permanent link (DOI): https://doi.org/10.7939/R3RH17

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NORMAL AND PATHOLOGICAL DEVELOPMENT OF THE RODENT PRIMORDIAL DIAPHRAGM Open Access

Descriptions

Other title
Subject/Keyword
Diaphragm -- Pathophysiology -- Animal models
Diaphragmatic hernia -- Pathogenesis
Mesenchymal stem cells
Phrenic nerve -- Cytology
Muscle cells -- Cytology
Diaphragm -- Research
Embryology -- Research
Mice -- Development
Mice -- Embryos
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Abou Marak Dit Roum, Darine
Supervisor and department
Dr. John Greer ( Department of Physiology)
Examining committee member and department
Dr. Simon Gosgnach (Department of Physiology)
Dr. Gregory Funk ( Department of Physiology)
Dr. Alan Underhill ( Department of Medical Genetics)
Department
Department of Physiology
Specialization

Date accepted
2011-01-27T21:21:49Z
Graduation date
2011-06
Degree
Master of Science
Degree level
Master's
Abstract
The focus of this thesis work was toward advancing our understanding of the normal and pathological development of the diaphragm. This included: (1) studies of the embryology of the primordial diaphragm tissue, the pleuroperitoneal fold (PPF), as it relates to congenital diaphragmatic hernia (CDH), and (2) investigating the relationship between migrating Schwann cells, phrenic axons and muscle cells in the developing diaphragm. The primary method of investigation was immunolabeling of the phrenic nerve, Schwann cells, muscle cells and the amuscular cellular component of the PPF and the diaphragm using the nitrofen model of CDH and transgenic mouse models. Together, these data provide the foundation for novel directions of research into CDH pathogenesis and specifically advance our understanding of: (1) the mechanism of CDH pathogenesis with special focus on PPF mesenchymal cells; and (2) the mechanism of axonal guidance and intramuscular branching.
Language
English
DOI
doi:10.7939/R3RH17
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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