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Permanent link (DOI): https://doi.org/10.7939/R3QZ22R7V

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Paclitaxel inhibits autophagy in breast cancer cells Open Access

Descriptions

Other title
Subject/Keyword
breast cancer
taxol
paclitaxel
apoptosis
autophagy
cell death
docetaxel
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Veldhoen, Richard
Supervisor and department
Goping, Ing Swie (Biochemistry, Oncology)
Examining committee member and department
Berthiaume, Luc (Cell Biology)
Goping, Ing Swie (Biochemistry, Oncology)
Bleackley, Chris (Biochemistry)
Department
Department of Biochemistry
Specialization

Date accepted
2012-06-08T11:21:15Z
Graduation date
2011-11
Degree
Master of Science
Degree level
Master's
Abstract
Taxanes are used for the treatment of breast, ovarian, and lung cancer. Unfortunately, taxane based therapy—the current treatment for metastatic breast cancer—has substantial shortcomings including myelosupression, neurotoxicity, and frequently acquired resistance. Our present understanding of taxane cytotoxicity is incomplete and prevents rational approaches to taxane improvement. Autophagy is a celluar process that digests portions of the cytosol to provide metabolic support in times of stress. This process is capable of promoting survival or conversely promoting cell death, depending on the context. The relationship between paclitaxel and autophagy is unclear. In this study, we show that paclitaxel causes inhibition of autophagy in breast cancer cells, both by decreasing autophagosome formation and by altering autophagosome trafficking and localization. Autophagy inhibition protects breast cancer cells against paclitaxel induced cell death, suggesting that manipulation of autophagy may represent a therapeutic target for improving breast cancer treatment options.
Language
English
DOI
doi:10.7939/R3QZ22R7V
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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