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Permanent link (DOI): https://doi.org/10.7939/R3WD83

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Understanding the Relationship Between Type 2 Diabetes and Bladder Cancer Open Access

Descriptions

Other title
Subject/Keyword
Systematic Review
Meta-Analysis
Detection Bias
Bladder Cancer
Pioglitazone
British Columbia
Pharmacoepidemiology
Type 2 Diabetes
Epidemiology
Cohort Study
Thiazolidinedione
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Colmers, Isabelle N.
Supervisor and department
Johnson, Jeffrey A. (School of Public Health Sciences)
Majumdar, Sumit R. (Faculty of Medicine and Dentistry)
Examining committee member and department
Yasui, Yutaka (School of Public Health)
Winget, Marcy (School of Public Health)
Department
School of Public Health Sciences
Specialization
Epidemiology
Date accepted
2012-08-23T15:00:32Z
Graduation date
2012-11
Degree
Master of Science
Degree level
Master's
Abstract
Individuals with type 2 diabetes (T2DM) have an increased risk of bladder cancer, relative to non-diabetic individuals. We aimed to investigate factors that may influence this association. Some reports suggest an association between the glucose-lowering drug pioglitazone and bladder cancer. Our first objective was to quantify the potential risk of bladder cancer with pioglitazone use, using meta-analytic techniques. Other studies observed a time-varying risk of cancer in T2DM. Our second objective was to assess temporal trends in the risk of bladder cancer in newly diagnosed T2DM vs. non-diabetic individuals. In our systematic review, we saw that pioglitazone use was associated with an increased risk of bladder cancer, but this was not seen with other drugs in the same class. In our administrative cohort study, bladder cancer risk was significantly elevated only in the first year following T2DM diagnosis, and only in the lowest category of physician visits before T2DM diagnosis.
Language
English
DOI
doi:10.7939/R3WD83
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Colmers IN, Bowker SL, Majumdar SR, and Johnson JA. Use of thiazolidinediones and the risk of bladder cancer among people with type 2 diabetes: a meta-analysis. CMAJ. [Epub ahead of print July 3, 2012]. doi:10.1503/cmaj.

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