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Permanent link (DOI): https://doi.org/10.7939/R3WD83
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Understanding the Relationship Between Type 2 Diabetes and Bladder Cancer Open Access
- Other title
Type 2 Diabetes
- Type of item
- Degree grantor
University of Alberta
- Author or creator
Colmers, Isabelle N.
- Supervisor and department
Johnson, Jeffrey A. (School of Public Health Sciences)
Majumdar, Sumit R. (Faculty of Medicine and Dentistry)
- Examining committee member and department
Yasui, Yutaka (School of Public Health)
Winget, Marcy (School of Public Health)
School of Public Health Sciences
- Date accepted
- Graduation date
Master of Science
- Degree level
Individuals with type 2 diabetes (T2DM) have an increased risk of bladder cancer, relative to non-diabetic individuals. We aimed to investigate factors that may influence this association.
Some reports suggest an association between the glucose-lowering drug pioglitazone and bladder cancer. Our first objective was to quantify the potential risk of bladder cancer with pioglitazone use, using meta-analytic techniques. Other studies observed a time-varying risk of cancer in T2DM. Our second objective was to assess temporal trends in the risk of bladder cancer in newly diagnosed T2DM vs. non-diabetic individuals.
In our systematic review, we saw that pioglitazone use was associated with an increased risk of bladder cancer, but this was not seen with other drugs in the same class. In our administrative cohort study, bladder cancer risk was significantly elevated only in the first year following T2DM diagnosis, and only in the lowest category of physician visits before T2DM diagnosis.
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- Citation for previous publication
Colmers IN, Bowker SL, Majumdar SR, and Johnson JA.
Use of thiazolidinediones and the risk of bladder cancer among people with type 2 diabetes: a meta-analysis.
CMAJ. [Epub ahead of print July 3, 2012]. doi:10.1503/cmaj.
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