ERA

Download the full-sized PDF of Maternal and fetal predictors of fetal viral load and death in third trimester, type 2 porcine reproductive and respiratory syndrome virus infected pregnant giltsDownload the full-sized PDF

Analytics

Share

Permanent link (DOI): https://doi.org/10.7939/R3736M291

Download

Export to: EndNote  |  Zotero  |  Mendeley

Communities

This file is in the following communities:

Roy Berg Kinsella Research Ranch

Collections

This file is in the following collections:

Journal Articles (Kinsella Ranch)

Maternal and fetal predictors of fetal viral load and death in third trimester, type 2 porcine reproductive and respiratory syndrome virus infected pregnant gilts Open Access

Descriptions

Author or creator
Ladinig, Andrea
Ashley, Carolyn
Detmer, Susan E.
Wilkinson, Jamie M.
Lunney, Joan K.
Plastow, Graham
Harding, John C.S.
Additional contributors
Subject/Keyword
Host Response
Transplacental Infection
Prenatal Undernutrition
Microscopic Lesions
Implantation Sites
Antibody-Response
Fetuses
PRRSV
Gestation
Sows
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Minimal research has focused on understanding mechanisms underlying porcine reproductive and respiratory syndrome virus (PRRSV) induced reproductive failure. We have completed a large-scale project investigating phenotypic and genotypic predictors of reproductive PRRS severity in which numerous clinical, pathological, immunologic and viral responses were characterized in dams and fetuses. The goal was to determine which phenotypic responses were associated with fetal viral load and death after experimental infection of pregnant gilts with type 2 PRRSV, thereby elucidating mechanisms of reproductive PRRS in third trimester pregnant gilts. The presence of fetal infection and increasing RNA concentration at the maternal-fetal interface were strong predictors of the probability of fetal death, while PRRSV RNA concentration in dam sera and systemic tissues were not associated with the odds of fetal death. Fetal infection and death clustered, indicating that the status of adjacent fetuses is crucial for lateral transmission and fetal outcome. Several systemic immune responses of gilts were associated with fetal outcome and viral load: interferon-α contributed to the probability of fetal death, but absolute numbers of T helper cells in early infection, absolute numbers of myeloid cells over time and interleukin 12 levels appeared protective. These results suggest specific immune responses may either contribute to, or protect against, transplacental virus transmission. The WUR10000125 SNP on chromosome 4, associated with PRRS resilience in nursery pigs, was not associated with reproductive outcome. Whereas past research suggested that fetal death results from events occurring at the maternal-fetal interface, we conclude that viral replication within fetuses and spread of PRRSV to adjacent fetuses are pivotal events in the pathogenesis of reproductive PRRS.
Date created
2015/09/25
DOI
doi:10.7939/R3736M291
License information
Attribution 4.0 International
Rights

Citation for previous publication
Ladinig, A., Ashley, C., Detmer, S.E., Wilkinson, J.M., Lunney, J.K., Plastow, G., Harding, J.C.S. (2015) Maternal and fetal predictors of fetal viral load and death in third trimester, type 2 porcine reproductive and respiratory syndrome virus infected pregnant gilts. Veterinary Research 46: 107
Source

Link to related item

File Details

Date Uploaded
Date Modified
2016-06-07T15:57:10.286+00:00
Audit Status
Audits have not yet been run on this file.
Characterization
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 3298377
Last modified: 2016:06:07 09:57:17-06:00
Filename: VR_46_107_1.pdf
Original checksum: 8b21cbdb41fa633766a5b177e349ad29
Well formed: true
Valid: false
Status message: Invalid destination object offset=3004550
Status message: Invalid destination object offset=3004550
Status message: Invalid destination object offset=3004550
Status message: Invalid destination object offset=3004550
Status message: Invalid destination object offset=3004550
File title: Abstract
File title: Maternal and fetal predictors of fetal viral load and death in third trimester, type 2 porcine reproductive and respiratory syndrome virus infected pregnant gilts
File author: Andrea Ladinig
Page count: 15
File language: EN
Activity of users you follow
User Activity Date