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Permanent link (DOI): https://doi.org/10.7939/R3XH6P

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Sustained Drug Release And Antibacterial Activity Of Ampicillin incorporated Poly (methyl methacrylate)-Nylon6 Core/Shell Nanofibers Open Access

Descriptions

Other title
Subject/Keyword
Antibacteria activity
Drug release
Electrospinning
Core/shell fibers
Kinetics of drug release
Drug delivery
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Sohrabi, Amirreza
Supervisor and department
Thundat, Thomas ( Department of Chemical and Materials Engineering)
Examining committee member and department
Thundat, Thomas ( Department of Chemical and Materials Engineering)
Narain, Ravin ( Department of Chemical and Materials Engineering)
Kaur, Kamiljit ( Department of Pharmacy and Pharmaceutical Science)
Department
Department of Chemical and Materials Engineering
Specialization
Materials Engineering
Date accepted
2012-09-17T09:39:02Z
Graduation date
2012-09
Degree
Master of Science
Degree level
Master's
Abstract
A drug delivery system was designed based on the encapsulation of Ampicillin sodium salt in Poly (methyl methacrylate)(PMMA)-Nylon6 core/shell nanofibers and the release characteristics and antibacterial activity of the system were investigated. It was revealed that the system is capable of releasing the drug with a sustained manner through a three stages release in which the release in stage I followed the non-Fickian diffusion; however, Fickian diffusion was proven to be the release mechanism of stages II and III. The diffusion coefficient calculations indicated a significant decrease in the coefficient from stage II to stage III which is believed to be the consequent of fibers crystallization as a result of the long-term incubation in an aqueous solution. Finally, the antibacterial activity of the system was verified by means of optical density (OD) measurements against gram positive L.innocua.
Language
English
DOI
doi:10.7939/R3XH6P
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
The Effect of Applied Electric Field on the Diameter and Size Distribution of Electrospun Nylon6 Nanofibers, Journal of Scanning Microscopies, DOI 10.1002/sca.21044.

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File author: Amirreza
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