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Permanent link (DOI): https://doi.org/10.7939/R37659N5N

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Fibre-Type Specific Nuclear Localisation Patterns of NFAT-isoforms in CLFS Induced Skeletal Muscle Adaptations Open Access

Descriptions

Other title
Subject/Keyword
myosin heavy chain
immunohistochemistry
skeletal muscle
Nuclear factor of activated T-cells
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
McDonald, Pamela C
Supervisor and department
Putman, Charles (Physical Education and Recreation)
Examining committee member and department
Bruce, Heather (Agriculture, Nutrition, and Food Science)
Dixon, Walter (Agriculture, Nutrition, and Food Science)
Delorey, Darren (Physical Education and Recreation)
Department
Physical Education and Recreation
Specialization

Date accepted
2014-01-28T13:16:01Z
Graduation date
2014-06
Degree
Master of Science
Degree level
Master's
Abstract
The purpose of this investigation was to characterize the nuclear localisation patterns of NFAT-c1, -c2, -c3, and -c4 in relation to chronic low-frequency stimulation induced fibre type transitions. A model has been suggested to describe the roles of all 4 NFAT isoforms in activity-dependent skeletal muscle fibre transformation. The findings of the present study are consistent with different yet related roles for the NFAT isoforms in fast-to-slow fibre type transformation. NFAT-c1 nuclear expression was associated with transition toward slower fibre types (type-I, type-IIA, type-IID(X)), whereas NFAT-c3 nuclear expression was associated with transformations surrounding the type-IIA fibres. The nuclear expression patterns of NFAT-c2 and NFAT-c4 are consistent with their involvement in fibre maintenance and cell survival.
Language
English
DOI
doi:10.7939/R37659N5N
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File author: Dr. Charles T. Putman
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