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Permanent link (DOI): https://doi.org/10.7939/R3BP4C

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New roles for B-cell lymphoma 10 in the nucleus Open Access

Descriptions

Other title
Subject/Keyword
γH2AX
DNA repair
Bcl10
NF-κB
DNA double strand break
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Dronyk, Ashley D
Supervisor and department
Shaw, Andrew (Oncology)
Examining committee member and department
Hendzel, Michael (Oncology)
Campbell, Shelagh (Biological Sciences)
Weinfeld, Michael (Oncology)
Department
Department of Oncology
Specialization

Date accepted
2010-12-09T21:52:04Z
Graduation date
2011-06
Degree
Master of Science
Degree level
Master's
Abstract
Radiation therapy targets cancer cell death by overwhelming cells with harmful DNA damage. Understanding how cells repair radiation damage and in particular how they become resistant to radiation therapy is important for effective cancer treatment. Our lab made the novel discovery that Bcl10, a cytoplasmic protein important for NF-κB activation, localizes to endogenous γH2AX foci in the nucleus of breast cancer cells. We determined that following radiation treatment Bcl10 is recruited to ionizing radiation-induced foci in a dose-dependent matter and that it is important for the repair of radiation-induced DNA damage. We also observed that breast cancer cells are extremely sensitive to Bcl10 knockdown, causing cellular senescence, while normal breast epithelial cells are insensitive. Our findings identify Bcl10 as potent anti-cancer target.
Language
English
DOI
doi:10.7939/R3BP4C
Rights
License granted by Ashley Dronyk (ashley.dronyk@gmail.com) on 2010-12-08T20:47:42Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File author: Ashley Dronyk
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