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Permanent link (DOI): https://doi.org/10.7939/R3W592

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Stochastic and deterministic models of cellular p53 regulation and drug response Open Access

Descriptions

Other title
Subject/Keyword
mdmx
stochastic
mdm2
model
p53
arf
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Leenders, Gerry B
Supervisor and department
Tuszynski, Jack (Physics)
Examining committee member and department
Marsh, Sharon (Pharmacy and Pharmaceutical Sciences)
Woodside, Michael (Physics)
Tuszynski, Jack (Physics)
Kurgan, Lukasz (Electrical & Computer Engineering)
Department
Department of Physics
Specialization

Date accepted
2012-09-26T09:34:11Z
Graduation date
2012-09
Degree
Master of Science
Degree level
Master's
Abstract
The protein p53 is a key regulator of cellular response to a wide variety of stresses. In cancerous cells inhibitory regulators of the p53 protein such as MDM2 and MDMX are often overexpressed. In silico techniques could be used to inform the selection of interactions to target with novel drug molecules to make the drug development process more efficient. This work furthers these efforts in two ways. Firstly by investigating some of the roles of stochasticity in determining system behavior, and secondly by developing a model of p53 MDM2 and MDMX interactions and attempting to use it to predict the best targets for future drugs. Stochasticity is shown to be able to effect system behavior profoundly, with implications for future work in both theory and experiment. Lack of experimental data is found to limit the effectiveness of attempts to theoretically determine good drug targets.
Language
English
DOI
doi:10.7939/R3W592
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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