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The Relationship (or Lack Thereof) Between Weight Loss and Health-Related Quality of Life in the Severely Obese Open Access


Other title
Weight Loss
Health Related Quality of Life
Type of item
Degree grantor
University of Alberta
Author or creator
Warkentin, Lindsey M
Supervisor and department
Majumdar, Sumit (Medicine)
Padwal, Raj (Medicine)
Examining committee member and department
Johnson, Jeff (School of Public Health)
Twells, Laurie (Medicine)
Department of Medicine
Experimental Medicine
Date accepted
Graduation date
Master of Science
Degree level
The impact of weight and weight loss on health-related quality of life (HRQL) in obese individuals and, in particular, the severely obese, is poorly understood. We completed a meta-analysis of published weight loss intervention trials; conducted cross-sectional analyses to examine covariate-adjusted associations between weight and HRQL in 500 severely obese patients; and performed a 2-year longitudinal analysis to determine the weight-loss thresholds associated with clinically important HRQL improvements these patients. Previous literature showed modest physical HRQL improvement with weight loss and no mental HRQL improvement. In the cross-sectional analyses, HRQL was substantially impaired in the severely obese; however, body mass index was only modestly associated with impaired HRQL. Over two years, weight reductions of about 20% were predicted to be required to achieve clinically important HRQL improvements. Overall, we found minimal association between body mass and HRQL in the severely obese. Marked weight reductions are expected to be required to achieve clinically important HRQL improvement.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Warkentin, LM, Das, D, Majumdar, SR, Johnson, JA and Padwal, RS. The effect of weight loss on health-related quality of life: systematic review and meta-analysis of randomized trials. Obesity Reviews. 2014 15: 169-182Warkentin, LM, Majumdar, SR, Johnson, JA, Agbrosangaya CB, Rueda-Clausen, CF, Sharma, AM, et al. Predictors or Health-Related Quality of Life in 500 Severely Obese Patients. Obesity. 2014 doi: 10.1002/oby.20694

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