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The Peroxin Pex34p Functions with the Pex11 Family of Proteins to Regulate the Peroxisome Population in the Yeast Saccharomyces cervisiae Open Access


Other title
Pex11 family
peroxisome division
Type of item
Degree grantor
University of Alberta
Author or creator
Tower, Robert J
Supervisor and department
Dr. Richard Rachubinski (Cell Biology)
Examining committee member and department
Dr. Michael Schultz (Biochemistry)
Dr. Gary Eitzen (Cell Biology)
Department of Cell Biology

Date accepted
Graduation date
Master of Science
Degree level
Peroxisomes are highly dynamic organelles that change in size and number in response to both intra- and extracellular cues. Peroxisome growth and division are controlled by the import of matrix proteins and by a specialized divisional machinery that includes peroxisome-specific factors, such as members of the Pex11 protein family, and general organelle divisional factors, such as the dynamin-related protein Vps1p. Here we show that Pex34p is a peroxisomal integral membrane protein that acts independently and together with the Pex11 protein family members Pex11p, Pex25p and Pex27p to control the peroxisome populations of cells under conditions of both peroxisome proliferation and constitutive peroxisome division. Pex34p can act as a positive effector of peroxisome division but requires the Pex11 family proteins. Our addition of Pex34p to the repertoire of proteins involved in regulating peroxisome division emphasizes the necessity of cells to strictly regulate their peroxisome populations.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Tower RJ, Fagarasanu A, Aitchison JD, Rachubinski RA. 2011. The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast. Mol. Biol. Cell. 22(10); 1727-1738.

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