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Permanent link (DOI): https://doi.org/10.7939/R3RW6X

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Allelic diversity of antigen processing genes in wild mallards Open Access

Descriptions

Other title
Subject/Keyword
peptide loading complex
transporter associated with antigen processing
antigen presentation
polymorphism
tapasin
MHC class I
mallard
adaptive immunity
diversity
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Petkau, Kristina
Supervisor and department
Magor, Katharine (Biological Sciences)
Examining committee member and department
Elliott, John (Medicine and Medical Microbiology & Immunology)
Gallin, Warren (Biological Sciences)
Department
Department of Biological Sciences
Specialization
Physiology, Cell and Developmental Biology
Date accepted
2012-08-29T11:58:46Z
Graduation date
2012-11
Degree
Master of Science
Degree level
Master's
Abstract
The recognition of virus infected cells by cytotoxic T lymphocytes is dependent on antigen presentation by MHC class I on the cell surface. Antigen presentation is critically dependent on the transporter associated with antigen processing (TAP), which facilitates the transport of peptides across the endoplasmic reticulum (ER) membrane. TAP specificity could affect the repertoire of peptides loaded on MHC class I. Here we analyzed the diversity of antigen presentation genes of 12 mallards, and the bidirectional promoter between TAP1 and TAP2. Alleles are from 94 - 100% similar with variation at 32 positions in TAP1 and 81 in TAP2. Non-conservative amino acid substitutions were observed in both TAPs, which align with peptide binding regions of the mammalian TAP. Polymorphism in functional regions of TAP could potentially restrict antigen presentation in ducks. This could contribute to the poor immune response to vaccines and the perpetuation of influenza virus in this host.
Language
English
DOI
doi:10.7939/R3RW6X
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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