ERA

Download the full-sized PDF of Phylogenetic Analysis of the MS4A and TMEM176 gene familiesDownload the full-sized PDF

Analytics

Share

Permanent link (DOI): https://doi.org/10.7939/R3348GS85

Download

Export to: EndNote  |  Zotero  |  Mendeley

Communities

This file is in the following communities:

Biological Sciences, Department of

Collections

This file is in the following collections:

Journal Articles (Biological Sciences)

Phylogenetic Analysis of the MS4A and TMEM176 gene families Open Access

Descriptions

Author or creator
Zuccolo, J.
Bau, J.
Childs, S.J.
Goss, G.G.
Sensen, C.W.
Deans, J.P.
Additional contributors
Subject/Keyword
protein
localization
expression
CD20
identification
Lymphocytes
channels
T-cells
Epsilon-Ri-Beta
Rituximab
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Background: The MS4A gene family in humans includes CD20 (MS4A1), FcRb (MS4A2), Htm4 (MS4A3), and at least 13 other syntenic genes encoding membrane proteins, most having characteristic tetraspanning topology. Expression of MS4A genes is variable in tissues throughout the body; however, several are limited to cells in the hematopoietic system where they have known roles in immune cell functions. Genes in the small TMEM176 group share significant sequence similarity with MS4A genes and there is evidence of immune function of at least one of the encoded proteins. In this study, we examined the evolutionary history of the MS4A/TMEM176 families as well as tissue expression of the phylogenetically earliest members, in order to investigate their possible origins in immune cells. Principal Findings: Orthologs of human MS4A genes were found only in mammals; however, MS4A gene homologs were found in most jawed vertebrates. TMEM176 genes were found only in mammals and bony fish. Several unusual MS4A genes having 2 or more tandem MS4A sequences were identified in the chicken (Gallus gallus) and early mammals (opossum, Monodelphis domestica and platypus, Ornithorhyncus anatinus). A large number of highly conserved MS4A and TMEM176 genes was found in zebrafish (Danio rerio). The most primitive organism identified to have MS4A genes was spiny dogfish (Squalus acanthus). Tissue expression of MS4A genes in S. acanthias and D. rerio showed no evidence of expression restricted to the hematopoietic system. Conclusions/Significance: Our findings suggest that MS4A genes first appeared in cartilaginous fish with expression outside of the immune system, and have since diversified in many species into their modern forms with expression and function in both immune and nonimmune cells.
Date created
2010
DOI
doi:10.7939/R3348GS85
License information
© 2010 Zuccolo et al. This is an...
Rights
© 2010 Zuccolo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Citation for previous publication
Zuccolo J, Bau J, Childs SJ, Goss GG, Sensen CW, et al. (2010) Phylogenetic Analysis of the MS4A and TMEM176 Gene Families. PLoS ONE 5(2): e9369. doi:10.1371/journal.pone.0009369
Source
Link to related item

File Details

Date Uploaded
Date Modified
2014-05-01T00:01:17.432+00:00
Audit Status
Audits have not yet been run on this file.
Characterization
File format: pdf (PDF/A)
Mime type: application/pdf
File size: 1830968
Last modified: 2015:10:12 20:47:07-06:00
Filename: PLOS_One_5_2010_1.pdf
Original checksum: ee2c864448b98d9aa93d38cf175303e5
Well formed: true
Valid: true
File title: pone.0009369 1..10
Page count: 10
Activity of users you follow
User Activity Date