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Permanent link (DOI): https://doi.org/10.7939/R3834W
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The pharmaceutical industry’s willingness-to-sell targeted chemotherapy for incurable solid cancers Open Access
- Other title
- Type of item
- Degree grantor
University of Alberta
- Author or creator
Conter, Henry J
- Supervisor and department
Menon, Devidas (Department of Public Health Sciences)
- Examining committee member and department
Butts, Charles (Department of Oncology)
Jhangri, Gian (Department of Public Health Sciences)
Klarenbach, Scott (Division of Nephrology)
McCabe, Chris (Department of Public Health Sciences)
School of Public Health Sciences
Health Technology Assessment
- Date accepted
- Graduation date
Master of Science
- Degree level
How the costs of research and its associated risks contribute to a minimum price that would support continued private pharmaceutical investment is unclear.
We employed a linear cost-volume-revenue breakeven analysis to equate initial capital investment and risk, and its associated post-drug-approval revenue. A decision-tree analytic model was utilized to define the relationships between investment events, outcomes, and risk. A systematic review was employed to determine the model inputs.
In oncology, the minimum revenue required to support R&D is $4.34 billion USD to $5.21 billion USD. The strategy undertaken to develop a new drug can reduce the associated revenue to $2.77 - $3.49 billion USD. Utilizing multi-tumour phase I clinical trials may allow for $853 million USD to $983 million USD in additional reductions.
The minimum required return on investment varies with estimates for cost of capital and the approach a firm uses when developing novel therapeutics.
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